方卫刚.C反应蛋白动态变化在感染性休克中的临床意义[J].内科急危重症杂志,2015,21(3):
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| DOI： |
| 中文关键词: C反应蛋白 感染性休克 APACHEⅡ评分 |
| 英文关键词:C reactive protein（CRP） Septic shock APACHEⅡ score |
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| 中文摘要: |
| 目的 探讨C反应蛋白（CRP）动态变化在感染性休克患者中的临床意义。 方法 检测45例感染性休克患者入院后第 1、3、5 天CRP， 记录APACHEⅡ评分，分成生存组和死亡组进行比较。 结果 两组性别、年龄比较差异无统计学意义（P>0.05），两组入院第1天CRP比较，差异无统计学意义（P>0.05），第3天、第5天死亡组CRP水平较生存组明显升高，差异有显著统计学意义（P<0.01）。两组的APACHEⅡ评分比较，差异有显著统计学意义（P<0.01）。第1天CRP与APACHEⅡ评分无相关性（r1=-0.082，P1=0.594），与预后无相关性（r1=0.182，P1=0.232）；第3天CRP、第5天CRP与预后呈明显正相关性（r3=0.469，P3=0.001；r5=0.428，P5=0.004）。CRP和APACHEⅡ评分ROC下面积分别为0.393，0.241。 结论 CRP的动态变化对判断感染性休克患者病情严重程度和预后有一定意义。 |
| 英文摘要: |
| [Abtract] Objective: Investigate the clinical significance of dynamic change of C reactive protein （CRP）in septic shock. Methods: The CRP levels were determined at the d1, d3 and d5 of admission and acute physiology and chronic health evaluationⅡscores was taked down in 45 cases of septic shock.They were compared according to survival or death. Results: No significant differences were found in the items such as age and sex among both groups(P>0.05). So did CRP of No.1 day (P>0.05). There were very significant differences on CRP of No.3 day and No.5 day between both groups(P<0.01) . So did APACHEⅡ scores. There were no significant correlation between CRP and APACHEⅡ scores（r1=-0.082，P1=0.594；r3=0.119，P3=0.435；r5= -0.028，P5=0.857）. So was between CRP of No.1 day and prognosis（r1=0.182，P1=0.232）. But there were very significant correlation between CRP of No.3 day and prognosis(r3=0.469，P3=0.001).So was between CRP of No.5 day and prognosis(r5=0.428，P5=0.004). .The areas of CRP and APACHEⅡ scores under the ROC curve were 0.393 and 0.241. Conclusion: Dynamic change of CRP could determine seriousness and prognosis in septic shock effectively. |
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