柳贵梅.课题名称：幽门螺杆菌感染与类风湿性关节炎的关系探索。鉴字2012第9——375.[J].内科急危重症杂志,2015,21(4):
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| DOI： |
| 中文关键词: 幽门螺杆菌 风湿性疾病 血沉 C 反应蛋白 |
| 英文关键词:Helicobacter pylori, Rheumatic diseases, ESR, C reactive protein |
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| 中文摘要: |
| 目的 探讨幽门螺杆菌(Helicobacterpylori,Hp)感染与风湿性疾病的关系。方法 采用14-Ｃ尿素呼气试验对221例风湿性疾病患者及100例健康对照者进行Hp检测,将所有风湿性疾病患者依据14-Ｃ尿素呼气试验结果分为Hp(+)组和Hp(-)组。所有风湿性疾病患者抽血检测血沉,C反应蛋白(CRP)。结果 1. 类风湿性关节炎(rheumatoid arthritis,RA)组、强直性脊柱炎(ankylosing spondylitis,AS)组、干燥综合征(sjogren"s syndrome ,SS)组中Hp阳性率较对照组高(67.33％ vs 36.00％,58.14％ vs 36.00％,57.69％ vs 36.00％,P<0.05),而系统性红斑狼疮(systemic lupus erythematosus,SLE)组、多发性肌炎/皮肌炎(dermatomyositis/polymyositis,PM/DM)组中Hp阳性率与对照组相比差异无显著性(39.29％ vs 36.00％,34.78％ vs 36.00％,P>0.05)。2. RA、SLE、PM/DM、AS、SS患者中Hp( )组的血沉、CRP水平较Hp(-)组高。结论 Hp感染可能与风湿性疾病尤其是RA、AS、SS密切相关。 |
| 英文摘要: |
| ［］ Objective To investigate the relationship between Helicobacter pylori (Hp)infection and rheumatic diseases. Method Helicobacter pylori were assessed by 14-Ｃurea breath test in 221patients with rheumatic diseases and in 100 healthy controls. All patients with rheumatic diseases are divided into Hp positive group and Hp negative group on the basis of 14-C urea breath test results. ESR, serum C reactive protein (CRP) were measured in all patients with rheumatic diseases. Results 1. The positive rate of Hp in the rheumatoid arthritis(RA) group, ankylosing spondylitis(AS) group, drying syndrome group(SS) was higher than that in the control group(67.33％ vs 36.00％,58.14％ vs 36.00％,57.69％ vs 36.00％,P<0.05),while there was no significantly diffenrence in the Systemic lupus erythematosus(SLE) group and in the dermatomyositis/polymyositis(PM/DM )group compared with the control group(39.29％ vs 36.00％,34.78％ vs 36.00％,P>0.05).2.The levels of ESR, CRP in the patients of RA, SLE, PM/DM, AS, SS with Hp ( ) were higher than those with Hp (-)(P<0.05).Conclusion There may be close relationship between the Hp infection and and rheumatic disease, especially RA, AS, SS. |
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