鳞状细胞癌抗原与原发性肝癌相关性研究进展
Associated progress between squamous cell carcinoma antigen and hepatocellular carcinoma

朱惠娜,田德英.鳞状细胞癌抗原与原发性肝癌相关性研究进展[J].内科急危重症杂志,2015,21(3):

扫码阅读全文

DOI：

英文关键词:

基金项目:

作者	单位	E-mail
朱惠娜	华中科技大学同济医学院附属同济医院	30789104@qq.com
田德英	湖北省武汉市华中科技大学同济医学院附属同济医院消化内科	dytian@tjh.tjmu.edu.cn

摘要点击次数: 2813

全文下载次数: 3684

中文摘要:

原发性肝癌(hepatocellular carcinoma,HCC)是世界第六大最常见的肿瘤,它进展迅速、转移率高,故早期诊断、及时治疗对其预后有重要意义。鳞状细胞癌抗原(squamous cell carcinoma antigen,SCCA)是一种肿瘤相关蛋白,其在HCC患者的血清和癌组织中的表达显著升高。SCCA在HCC组织中的表达可作为早期诊断小肝癌结节及肝组织中微转移病灶的标记。血清SCCA的检测对于早期诊断HCC的敏感性优于AFP。SCCA与AFP联合应用可以提高HCC诊断的灵敏度。因此,SCCA可作为诊断HCC的一种新的肿瘤标志物。

英文摘要:

Hepatocellular carcinoma(HCC)is the 6_th most common tumour in the world.Because its rapid progress and high transfer rate,early diagnosis and prompt treatment are important to HCC patients" prognosis. Squamous cell carcinoma antigen(SCCA) was a tumor-associated protein.The SCCA serum levels and the express of SCCA in the tumoral tissues of HCC patients is obviously higher. SCCA expression in HCC tissues can serve as an early diagnosis mark of small HCC and liver tissue micro-metastases. Serum SCCA testing for early diagnosis of HCC is better than AFP. The combined use of SCCA and AFP can improve the sensitivity of the diagnosis of HCC. So,SCCA may become a new tumor maker for HCC.