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林书生.机械通气联合纳洛酮治疗慢性阻塞性肺疾病合并呼吸衰竭的疗效观察[J].内科急危重症杂志,2015,21(6):
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| DOI： |
| 中文关键词: 机械通气 纳洛酮 慢性阻塞性肺疾病 呼吸衰竭 |
| 英文关键词:mechanical ventilation naloxone chronic obstructive pulmonary disease respiratory failure |
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| 摘要点击次数: 3014 |
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| 中文摘要: |
| 目的 观察机械通气联合纳洛酮治疗慢性阻塞性肺疾病(简称慢阻肺)并发呼吸衰竭的疗效。方法 选择在我院ICU予有创机械通气治疗的慢阻肺并发呼吸衰竭患者73例,视是否使用纳洛酮分为治疗组和对照组,观察治疗前及治疗24h后血气指标、呼吸频率、心率、无创血压、5天内有效脱机率、有创机械通气时间、住ICU时间、7日病死率和28日病死率。结果 两组患者间pH、PO2、PCO2、呼吸频率、心率、血压等均无明显差异,治疗组有效脱机率明显增高(88.57%vs68.42%,p＜0.01),机械通气时间(2.93±1.05d vs 4.76±4.45d)、住ICU时间(5.17±2.12d vs 7.42±5.67d)明显缩短(p＜0.05),7日病死率(2.86% vs 13.16%,p＜0.05)和28日病死率(14.29% vs 34.21%,p＜0.05)明显降低,与对照组比较有统计学差异。结论 机械通气联合纳洛酮治疗慢阻肺并发呼吸衰竭可以提高有效脱机率,缩短机械通气时间和住ICU时间,降低病死率。 |
| 英文摘要: |
| Objective To observe the effect of mechanical ventilation combined with naloxone in the treatment of patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods 73 patients with COPD complicated with respiratory failure divided into combined naloxone group which was given mechanical ventilation combined with naloxone and mechanical ventilation group which was given only mechanical ventilation. The clinical effect was observed and compared between the two groups. Results There were no significant differences between the two groups of patients at blood gas analysis, respiratory rate, heart rate, blood pressure. The rate of stop using mechanical ventilation was significantly higher in combined naloxone group than mechanical ventilation group (88.57%vs68.42%, P < 0.01). The combined naloxone group were significantly shorten the duration of the mechanical ventilation (2.93 ± 1.05dvs4.76 ± 4.45d) and in ICU stay (5.17 ± 2.12 d vs7.42 ± 5.67d) than mechanical ventilation group (P< 0.05). The combined naloxone group were significantly lower 7d mortality (2.86% vs 13.16%, P< 0.05) and 28d mortality (14.29% vs 34.21%, P< 0.05) than mechanical ventilation group. Conclusion Mechanical ventilation combined with naloxone in the treatment of patients with COPD combined with respiratory failure can improve the rate of stop using mechanical ventilation, shorten the duration of the mechanical ventilation and in ICU stay. |
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