阻塞性睡眠呼吸暂停综合征患者血栓形成前状态分子与颈动脉内膜中层厚度关系
Correlation between pre-thrombotic state and intima-madia thickness of carotid artery in patients with obstructive sleep apnea hypopnea syndrome YU Kun-cheng ,XIE Jiang-xia_※ ,YANG Shu-kun,ZHANG Xiao-yu. Longgang District People’s Hospital of ShenZhen,ShenZhen,518172,China

余坤城,谢江霞,阳书坤,张晓瑜.阻塞性睡眠呼吸暂停综合征患者血栓形成前状态分子与颈动脉内膜中层厚度关系[J].内科急危重症杂志,2015,21(4):

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英文关键词:obstructive sleep apnea syndrome pre-thrombotic state intima-madia thickness

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作者	单位	E-mail
余坤城	深圳市龙岗区人民医院	ykc163@163.com
谢江霞	深圳市龙岗区人民医院	doctoranna@126.com
阳书坤	深圳市龙岗区人民医院
张晓瑜	深圳市龙岗区人民医院

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中文摘要:

目的：探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血栓形成前状态(PTS)分子标志物与颈动脉内膜中层厚度关系。方法：选择OSAHS患者56例和对照组28例,采用采用酶联免疫吸附法测定血清血小板颗粒膜蛋白-140(GMP-140)、血管性血友病因子(vWF)和抗凝血酶Ⅲ(ATⅢ)水平,采用底物发光法测定组织型纤溶酶原激活剂(t-PA)和血浆纤溶酶原激活物抑制剂1(PAI-1)水平；使用彩色多普勒超声检测颈动脉内膜中层厚度(IMT)。结果：OSAHS组血清GMP-140、vWF、Fbg、PAI-1水平高于对照组,血清ATⅢ、t-PA水平低于对照组,颈动脉内膜中层厚度高于对照组(P均＜0.05)。血清GMP-140、vWF、Fbg、PAI-1水平与IMT呈正相关(r=0.507,0.411,0.392和0.458,均P＜0.05)。血清ATⅢ、t-PA水平与IMT呈负相关(r=-0.401,-0.367,均P＜0.05)。OSAHS患者GMP-140、vWF、t-PA水平与IMT成线性回归关系。结论：OSAHS患者存在着明显的PTS,同时颈动脉内膜增厚明显。PTS是导致患者颈动脉内膜增厚的重要因素之一。

英文摘要:

Objective: To analysis the correlation between pre-thrombotic state and intima-madia thickness (IMT) of carotid artery in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: 56 OSAHS patients(OSAHS group) and 28 healthy voluntrers (control group) were recruited in the study.The levels of serum granular membrane protein (GMP-140), von willebran factor(vWF), antithrombin Ⅲ(ATⅢ) were test by enzyme-linked immunosorbent assay.The states of IMT of carotid artery were evaluated by ultrasonic imagingmethod and the tissue-type plasminogen (t-PA), plasminogen activator inhibitor-1(PAI-1) were test by Substrate chemiluminescence method. Results: Compared to the control group, the levels of serum GMP-140, vWF, Fbg, PAI-1 and were IMT of carotid artery significantly higher in patients with OSAHS(P＜0.05). On the contrary,the levels of ATⅢ and t-PA were significantly lower in OSAHS group. The IMT of carotid artery were positive correlation to GMP-140,vWF,Fbg,PAI-1 (r=0.507,0.411,0.392 and 0.458), which were negatively correlated to the ATⅢ and t-PA (r=-0.401,-0.367), all P＜0.05. The IMT of carotid artery were in multiple linear regression with AHI, MSaO2 and serum GMP-140,vWF ,t-PA levels. Conclusions: The levels of serum PTS were increased and IMT of carotid artery existed in OSAHS patients. The PTS was the important factors in in OSAHS patients with IMT.