百草枯中毒普萘洛尔的解毒治疗有效性研究_{湖北省新华医院重症医学科}_郭俊
Research on treatment effectiveness of propranolol paraquat for poisoning detoxification

郭俊.百草枯中毒普萘洛尔的解毒治疗有效性研究_{湖北省新华医院重症医学科}_郭俊[J].内科急危重症杂志,2016,22(2):

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英文关键词:: paraquat poisoning propranolol detoxicate

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作者	单位	E-mail
郭俊	湖北省中西医结合医院	625246269@qq.com

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中文摘要:

【】目的：探讨普萘洛尔对百草枯(paraqua,PQ)中毒的解毒治疗的临床效果。方法：回顾性分析2008年9月～2015年2月期间,我院收治的100例百草枯中毒患者,其中50例患者给予常规治疗,作为对照组,50例患者在给予常规治疗基础上,早期应用普萘洛尔治疗,作为治疗组。然后将对照组患者与治疗组患者的治疗效果进行比较。结果：治疗组患者的总有效率优于对照组,组间有显著差异(P＜0.01)。其中,在轻中度中毒患者中,治疗组患者的总有效率优于对照组,组间有显著差异(P＜0.01)；在重度中毒患者中,治疗组患者的总有效率与对照组间差异无统计学意义(P>0.05)。比较治疗组患者不同病情的治疗总有效率,轻中度中毒患者的治疗有效率明显高于重度中毒患者,组间有显著差异(P＜0.01)。比较治疗组并发症的发生率及死亡率明显低于对照组,组间均有显著差异(P＜0.01)。其中,在轻中度中毒患者中,治疗组患者的并发症发生率及死亡率明显低于对照组患者,组间有显著差异(P＜0.01)；在重度中毒患者中,两组患者的并发症发生率及死亡率无统计学差异(P>0.05)。比较治疗组不同病情患者的并发症发生率及死亡率,轻中度中毒患者的并发症发生率及死亡率明显低于对照组患者,组间有显著差异(P＜0.01)。结论：在常规治疗基础上,早期给予患者普萘洛尔治疗,能够提高轻中度中毒患者的治疗效果,降低轻中度中毒患者死亡率,但对于重度中毒患者并无特殊疗效。应继续研究百草枯中毒的特异性拮抗剂来降低死亡率。

英文摘要:

[Abstract] Objective: To investigate the clinical effects of propranolol detoxification treating paraquat poisoning. Methods: Took a retrospective analysis of 100 cases of paraquat poisoning patients from September 2005 - February 2015 in our hospital, 50 patients were treated with conventional therapy, as the control group, 50 patients received conventional treatment based on the early propranolol therapy, as the treatment group. Then the treatment of patients in control group and treatment group were compared. Results: The total effective rate in treatment group was better than control group, difference between groups was statistically significant (P <0.01). In the mild and moderate poisoning group,the total effective rate in treatment group was better than control group, difference between groups was statistically significant (P <0.01). In the severe intoxication group, difference of the total effective rate between groups was not statistically significant (P>0.05).Compare the total effective rate in the different condition of treatment group, the mild and moderate poisoning group was much higher than the severe intoxication group, difference between groups was statistically significant (P <0.01). The occurrence rate of complications and mortality in treatment group was lower than control group,difference between groups was statistically significant (P <0.01). In the mild and moderate poisoning group, the occurrence rate of complications and mortality was much lower than control group, difference between groups was statistically significant (P <0.01). In the severe intoxication group, difference of the occurrence rate of complications and mortality between groups was not statistically significant (P>0.05). Compare the occurrence rate of complications and mortality in the different condition of treatment group, the mild and moderate poisoning group was much lower than the severe intoxication group, difference between groups was statistically significant (P <0.01).Conclusion: In conventional therapy, giving patients early treatment with propranolol, can improve the therapeutic effect and reduce mortality in the mild and moderate poisoning patients, but have no special effects in the severe intoxication patients .We should research specific antagonist.of paraquat to reduce mortality.