沈梅竹,胡国清.鼻咽癌患者营养状态变化调查华中科技大学同济医学院附属同济医院 沈梅竹龙国贤 孙伟 张琳丽 罗敏 胡国清*,武汉 430030[J].内科急危重症杂志,2015,21(5):
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| DOI： |
| 中文关键词: 诱导化疗 同步放化疗 鼻咽癌 营养状态 |
| 英文关键词:induction chemotherapy concurrent chemoradiotherapy nasopharyngeal carcinoma nutritional status |
| 基金项目:国家自然科学基金项目（81272491） |
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| 中文摘要: |
| 目的：观察接受诱导化疗联合同步放化疗治疗鼻咽癌患者的营养状态。方法：纳入117例鼻咽癌初治患者,采用病人提供的主观整体营养状况评量表(PG-SGA)在治疗及随访过程中定期进行问卷式调查,同时行血液学检查,了解患者的营养状态。结果：鼻咽癌患者接受诱导化疗及放疗后血红蛋白及血清前白蛋白水平减低发生率均显著增加,治疗后缓慢恢复；主观整体营养状态在诱导化疗后略有改善,同步放化疗后显著恶化,治疗后12月内缓慢恢复至治疗前水平。结论：接受诱导化疗联合同步放化疗的鼻咽癌患者,血清营养状态及主观营养状态在治疗过程中均会明显受化疗及同步放化疗影响,应重视患者治疗过程中营养状态的变化,给予患者个体化饮食咨询和积极的营养支持治疗。 |
| 英文摘要: |
| objective: To investigate the nutritional status of patients with nasopharyngeal carcinoma(NPC) receiving induction chemotherapy combined concurrent chemoradiotherapy. Method: 117 primary treated nasopharyngeal patients are included and investigated with Scored Patient-Generated Subjective Global Assessment (PG-SGA) during the treatment and follow-up. Hematological examinations are checked at the same time to uncover the patients’ nutritional status. Result: The reducing rate of hemoglobin and prealbumin level of patients with nasopharyngeal carcinoma increase statistically when receiving induction chemotherapy combined concurrent chemoradiotherapy, and recover slowly then. Subjective Global Assessment is improved slightly after induction chemotherapy and worsen significantly when receiving concurrent chemoradiotherapy, then recover slowly in the next 12 months. Conclusion: The serum nutritional status and Subjective Global Assessment of NPC patients receiving induction chemotherapy combined concurrent chemoradiotherapy are influenced significantly. More attentions should be focused on the nutritional status, furthermore, individualized dietary counseling and active nutritional support treatments are needed. |
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