陈金亮.CAP患者呼出气冷凝液中PCT检测的临床意义[J].内科急危重症杂志,2016,22(1):
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| DOI： |
| 中文关键词: 社区获得性肺炎 呼出气冷凝液 降钙素原 CURB-65评分 临床意义 |
| 英文关键词: |
| 基金项目:南通市科技计划项目(HS149031) 徐永谦 陶一江 陈建荣 |
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| 中文摘要: |
| 【】目的 通过对社区获得性肺炎(CAP)患者呼出气冷凝液(EBC)中降钙素原(PCT)的检测,探讨其在CAP患者病情评估及疗效评价中的价值。方法 选择72例CAP住院患者,收集患者第1、3、7天的EBC及血清标本,并记录患者入院时白细胞计数、C反应蛋白(CRP)、CURB-65评分。选择健康体检者48例,收集其EBC及血清。结果 ①CAP患者EBC中PCT水平高于正常对照组,P﹤0.01；②与第1天比较CAP患者第3天和第7天EBC中PCT水平下降,差异具有统计学意义(P﹤0.01)；③EBC中PCT水平在高危组、中危组和低危组3组间的差异具有统计学意义(P＜0.01)；④EBC中PCT水平和血PCT、血CRP、WBC水平和CURB-65评分皆呈正相关。结论 CAP患者EBC中PCT水平与患者病情严重程度具有较好的相关性,是判断CAP严重程度和预后的敏感指标。 |
| 英文摘要: |
| 【】Objective To study the changes and clinic significances of procalcitonin (PCT) in exhaled breath condensate(EBC)in patients of community-acquired pneumonia (CAP). Methods We selected 72 cases of the CAP hospitalized patients, and according to CAP guidelines given regular treatment, collected their EBC samples in the 1,3,7 day, and recorded their leukocyte count, C-reactive protein(CRP) , CURB-65 score. We also selected 48 cases of the healthy examination people, collected their EBC and serum samples. Results①Compared with the healthy control group, the PCT levels in EBC were higher (P <0.01).②Compared with the first day, PCT levels in EBC were decreased in day 3 and day 7, the difference were statistically significant (P<0.01).③The EBC level of PCT in high score group was higher than that in median score group and that in low score group,differences were statistically significant(P<0.01)．④The EBC level of PCT had positive relationship with the CURB-65 score, serum PCT, CRP and WBC, P＜0.01. Conclusions There is a good correlation between the EBC level of PCT and the severity of the disease,suggesting that PCT to be a sensitive predictor of severity and prognosis of the CAP． |
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