低危原发性血小板增多症(ET)患者的临床特征和血栓危险因素分析研究
Clinical characteristics and risk factors analysis of patients with low risk of essential hypertension (ET)

李小妮.低危原发性血小板增多症(ET)患者的临床特征和血栓危险因素分析研究[J].内科急危重症杂志,2016,22(5):

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英文关键词:thrombosis risk factors essential thrombocythemia clinical features

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作者	单位	E-mail
李小妮	陕西省宝鸡市中心医院 721008	lixiaonitg@163.com

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中文摘要:

【】目的：总结低危原发性血小板增多症(ET)患者的临床特征,分析ET的血栓危险因素。方法：选取我院收治的151例低危原发性血小板增多症患者作为研究对象,回顾性分析本组患者的临床资料。结果：JAK2 V617F突变阳性组的WBC、中性粒细胞、HGB水平均显著高于阴性组,PLT水平显著低于阴性组,阳性组的严重血栓事件发生率显著高于阴性患者(P<0.05)。伴CVF患者的血栓发生率显著高于不伴CVF者(P<0.05)。多因素分析显示CVF、JAK2 V617F突变均是低危ET患者血栓事件的独立危险因素。结论：低危原发性血小板增多症患者发生血栓事件的独立危险因素为心血管危险因素和JAK2 V617F基因突变,临床上应根据低危ET患者的危险因素来制定相应的治疗方案。

英文摘要:

Objective: To summarize the clinical featuresthe of low-risk essential thrombocythemia (ET) patients, analysis of risk factors for thrombosis of ET. Methods: Selected 151 cases low-risk ET patients of our hospital as research subjects, and retrospective analysis of clinical data in this group of patients.Results: WBC, neutrophil and HGB levels of JAK2 V617F mutation positive group were significantly higher than the negative group, PLT level was significantly lower than the negative group, the incidence of serious thromboembolic events were significantly higher than the positive-negative patients (P <0.05). Multivariate analysis showed that CVF, JAK2 V617F mutation in low-risk ET patients are independent risk factors for thrombotic events.Conclusion: Low-risk ET patients? independent risk factors include cardiovascular risk factors and JAK2 V617F mutation, should be based on clinical risk factors for low-risk ET patients to develop appropriate treatment programs.