• 急性颅脑疾病患者早期血流动力学监测对预后影响的研究
  • Study on the effect of early hemodynamic parameters on the prognosis of patients with acute cerebral disease in ICU
  • 王征,骆勇,贾文钗,张晓燕,宁辉,贺春晖,钟春妍.急性颅脑疾病患者早期血流动力学监测对预后影响的研究[J].内科急危重症杂志,2016,22(3):
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    DOI:
    中文关键词:  急性颅脑疾病  血流动力学  PICCO
    英文关键词:Acute brain disease  hemodynamics  PICCO
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    作者单位E-mail
    王征 北京大学首钢医院重症医学科 493486375@qq.com 
    骆勇 北京大学首钢医院重症医学科  
    贾文钗 北京大学首钢医院重症医学科  
    张晓燕 北京大学首钢医院重症医学科  
    宁辉 北京大学首钢医院重症医学科  
    贺春晖 北京大学首钢医院重症医学科  
    钟春妍 北京大学首钢医院重症医学科  
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    中文摘要:
          目的:了解ICU中急性颅脑疾病患者早期的全身血流动力学指标对预后的影响。方法:本研究回顾性调查了2009年1月~2012年12月共55例由于急性颅脑疾病而收住我院综合ICU患者病历资料,55例均收集患者年龄、性别、APACHE II评分、格拉斯哥评分、转归等一般资料,以及颅脑疾病类别、高血压病、冠心病、心功能不全、糖尿病等病史以及发病期间有无肾功能不全、肺部感染、呼吸衰竭等临床诊断资料;均于发病6小时内置入PICCO监测导管应用PULSION PiCCO plus容量监测仪对患者血流动力学指标进行测定连续3天,收集主要血流动力学指标包括心功能指数(CFI)、全心射血分数(GEF)、左心室收缩指数(dPmax)、心指数(CI)、每搏量指数(SVI)、全心舒张末期容积指数(GEDI)、胸腔内血容积指数(ITBI)、全身血管阻力指数(SVRI)、血管外肺水指数(EVLWI)、肺血管通透性指数(PVPI)。根据患者28天转归情况分为死亡组33例和存活组22例,分析2组患者上述指标间的差异,同时运用多因素 Logistic回归方法分析可能对预后产生影响的因素。结果:2组患者格拉斯哥评分、年龄、有无呼吸衰竭等情况差异有显著性(P<0.05),校正上述因素的方差分析后显示,2组患者在发病后第一天dPmax、EVLWI,第二天CFI、dPmax、CI、SVRI、EVLWI,第三天EVLWI差异有显著性(P<0.05),然后运用多因素 Logistic回归分析对上述有显著差异的一般因素及血流动力学指标进行分析,结果年龄、第一天dPmax、EVLWI及第二天CI均为影响预后的独立因素(P分别为0.014,0.026,0.010和0.020,OR值分别为0.747,1.009,5.397及0.038)。结论:急性颅脑损伤患者早期的全身血流动力学第一天dPmax、EVLWI及第二天CI影响患者预后。
    英文摘要:
          Objective  To find the effect of early hemodynamic parameters on the prognosis of patients with acute cerebral disease in ICU.Methods  About fifty-five patients with acute cerebral disease in ICU from January 2009 to December 2012 were retrospective reviewed.All the patients were accepted PICCO catheter to monitoring hemodynamic parameters.Thegeneral informations of age,sex,APACHE II score,Glasgow score and outcome were collected.The clinical diagnostic datum of the kind of cerebral disease,hypertension, coronary heart disease, heart failure, diabetes,renal dysfunction, pulmonary infection and respiratory failure were also collected.The hemodynamic parameters includedCFI,GEF,dPmax,CI,SVI,GEDI,ITBI,SVRI,EVLWI and PVPI of first three days.The patients were divided into death group and survival group according to the 28 day outcome.To analyze the differences of these parameters between the two groups, and to analyze the factors affecting the prognosis of the patients with multiple linear regression analysis.Results There were significant differences in theGlasgow score, age and having respiratory failure of the two groups(P<0.05).After adjusting those factors,there were significant differences in dPmax and EVLWI on first day,and there were also significant differences in CFI,dpmax,CI,SVRI,EVLWI on second day and EVLWI on third day. Then the datum above were analysed with Logistic regression analysis,and the result showed that the age(P=0.014,OR=0.747),dpmax on first day(P=0.026,OR=1.009),EVLWI on first day(P=0.010,OR=5.397),and CI on the second day(P=0.020,OR=0.038),)were all the the independent factors affecting the prognosis of the patients.Conclusion The early hemodynamic parameters of patients with acute cerebral disease can affect prognosis.