黄维国.PCT诊断危重感染临床分析[J].内科急危重症杂志,2017,23(3):
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| DOI： |
| 中文关键词: 降钙素原 脓毒症 预后 |
| 英文关键词:Sepsis prognosis procalcitonin |
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| 中文摘要: |
| 【】 目的 探讨降钙素原(PCT)在危重感染患者临床病情评估、预后预测中的价值。方法 选取本院重症监护病房(ICU)2012年2月～2015年7月收治的139例脓毒症患者作为研究对象,根据患者入住ICU 24h内的基本情况将患者分为脓毒症组47例、严重脓毒症组54例和脓毒症休克组38例,分别对比三组患者的血清PCT水平、急性生理与慢性健康评分(APACHEⅡ)、全身性感染相关气管衰竭评分(SOFA)等指标,并根据患者治疗结局分为存活组和死亡组进行亚组分析。结果 入住ICU 24h内,脓毒症患者的PCT、WBC、CRP、APACHEⅡ评分、SOFA评分在不同病情分组患者间的水平为脓毒症组<严重脓毒症组<脓毒症休克组患者且差异均具有统计学意义(P<0.05)；入住ICU 24h内,脓毒症患者的PCT水平与患者WBC、CRP、APACHEⅡ评分、SOFA评分均呈显著的正相关关系(P<0.05)；ICU期间,存活脓毒症患者的PCT、WBC、CRP、APACHEⅡ评分、SOFA评分均呈显著的正低于死亡组患者(P<0.05)； PCT判断患者预后的最佳临界值为19.84ng/ml,此时的ROC曲线下面积AUC值为0.857,灵敏度为89.27%,特异度为86.34%。结论 PCT在危重感染患者临床病情评估、预后预测中具有较高的临床价值。 |
| 英文摘要: |
| 【】Objective To investigate the value of PCT in predicting the clinical severity and prognosis in critically ill patients. Methods Selected the hospital intensive care unit (ICU) 2012 年 from 2 months to July 2015 were treated 139 cases of sepsis patients as research subjects, according to the basic situation of patients admitted to the ICU within 24h Patients were divided into sepsis group 47 cases, 38 cases of 54 patients with severe sepsis and septic shock group were serum PCT levels compare three groups of patients, acute physiology and chronic health evaluation (APACHEⅡ), systemic infection trachea failure assessment (SOFA) and other indicators, and according to the outcome of patients divided into survival group and the death group subgroup analyzes. Results ICU admission within 24h, patients with sepsis PCT, WBC, CRP, APACHEⅡ score, SOFA score between groups of patients with different levels of disease in sepsis group |
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