阿司匹林在不同年龄段脑梗死患者中二级预防的研究
Aspirin in patients with cerebral infarction at different ages in secondary prevention

苏达京.阿司匹林在不同年龄段脑梗死患者中二级预防的研究[J].内科急危重症杂志,2017,23(1):

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英文关键词:aspirin cerebral infarction age secondary prevention subarachnoid hemorrhage

基金项目:基金项目：HA1077对脑梗塞急性期脑保护的研究基金编号：201392860

作者	单位	E-mail
苏达京	南宁市第二人民医院	sudajing482@163.com

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中文摘要:

目的：探讨阿司匹林在不同年龄段脑梗死患者中二级预防的效果。方法：将脑梗死患者分为暴露组（服用阿司匹林）与非暴露组（不服用阿司匹林或任何抗血小板药物），回顾性分析不同年龄段（41-50岁，51-60岁，61-70岁，71-80岁，81-90岁）脑梗死的复发，脑出血，蛛网膜下腔出血或者消化道出血的发生率情况。结果：各个年龄段暴露组脑梗死的复发明显低于非暴露组（P＜0.05），而上消化道出血则明显高于非暴露组（P＜0.05）；在61-90年龄段暴露组脑出血和蛛网膜下腔出血增加趋势显著低于非暴露组（P＜0.05）。41-80岁年龄段，各暴露组脑出血率与蛛网膜下腔出血率没有显著变化（P＞0.05），而在71-90岁之间，各暴露组脑出血率与蛛网膜下腔出血率显著增加（P＜0.05）。需治疗例数在71-90岁年龄段发生显著性增加（P＜0.05）；在61-70岁年龄段相对危险度最高，81-90岁年龄段归因危险度最大。结论：阿司匹林在不同年龄段脑梗死患者中二级预防效果存在差别，41-60岁之间应用阿司匹林进行二级预防获益最大，风险最小。

英文摘要:

Objective: To investigate aspirin in patients with cerebral infarction at different ages in secondary prevention effect. Methods: The cerebral infarction patients were divided into exposure group (aspirin) and non-exposed group (not taking any aspirin or antiplatelet drugs), a retrospective analysis of different age groups (41-50 years, 51-60 years, 61-70 years , 71-80 years, 81-90 years) recurrence of cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage or gastrointestinal bleeding incidence situation. Results: The recurrence of cerebral infarction of all ages exposed group was significantly lower than non-exposed group (P <0.05), and upper gastrointestinal bleeding was significantly higher than the non-exposed group (P <0.05); in the 61 - 90 age group exposed brain hemorrhage and subarachnoid hemorrhage increasing trend was significantly lower than non-exposed group (P <0.05). 41-80 age group, the rate of each exposure group cerebral hemorrhage and subarachnoid hemorrhage rate did not change significantly (P> 0.05), and between 71-90 years of age, each exposure group cerebral hemorrhage and subarachnoid hemorrhage rate was significantly increased (P <0.05). Significantly increased (P <0.05) takes several Cases occur in 71-90 age group; relative risk for the highest degree of 61-70 years of age, 81-90 years of age attributable risk maximum. Conclusion: Aspirin differ in different age groups in patients with cerebral infarction secondary prevention effect, aspirin for secondary prevention among 41-60-year-old to benefit the most, the least risk.