血清癌胚抗原水平与肝细胞肝癌预后的相关性探讨
The correlation between serum CEA levels and HCC prognosis

向田.血清癌胚抗原水平与肝细胞肝癌预后的相关性探讨[J].内科急危重症杂志,2017,23(3):

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英文关键词:Serum Carcinoembryonic antigen Hepatocellular carcinoma Prognosis

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作者	单位	E-mail
向田	湖北省恩施州中心医院西医部检验科	xiangtiantg@163.com

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中文摘要:

【】目的：探讨血清癌胚抗原水平与肝细胞肝癌预后的相关性探讨。方法：回顾性分析我院2012年1月至2014年1月期间消化外科住院部收治的肝细胞肝癌118例,根据手术前血清癌胚抗原(CEA)水平将患者分为三组,其中CEA<5μg/l作为A组,CEA=5-15μg/l作为B组,CEA>15μg/l作为C组,比较三组间组织分化程度、生存率与复发率的差异。结果：三组间高、中、低分化程度所占比例分别为(A组：34.29%、57.14%,8.57%),(B组：2.50%,50.00%,47.50%),(C组：2.33%,23.26%,74.42%),比较差异具有统计学意义(P<0.05)。A组手术后1.5年生存率明显高于C组,复发率明显低于C组,比较差异具有统计学意义(P<0.05)。A组手术后2年生存率明显高于B、C组,A、B组手术后2年复发率明显低于C组,比较差异具有显著性(P<0.05)。经Pearson相关性分析显示,血清CEA水平与生存率呈负相关(r=-3.536,P=0.009),与复发率呈正相关(r=0.412,P=0.009)。结论：血清CEA水平与肝细胞肝癌预后状况具有紧密的关系。

英文摘要:

Objective: To discuss the correlation between serum carcinoembryonic antigen levels and prognosis of HCC.Methods: 118 cases hepatocellular carcinoma from our hospital during the period of January 2012 and January 2012 from digestive surgery admitted inpatient were retrospectively analyzed, according to the preoperative serum carcinoembryonic antigen (CEA) levels,all were divided into three groups, CEA < 5 μg/l were as A group,CEA = 5-15 μg/l were as B group , CEA > 15 μg/l were as C group , the difference of differentiation degree, survival and recurrence rate among the three groups were compared.Results:The proportion of high, medium and low differentiation degree among the three groups were respectively (Agroup : 34.29%, 57.14%, 8.57%), (B group: 2.50%, 50.00%,47.50%), (C group: 2.33%, 23.26%,74.42%), and the comparative differences were statistically significant (P < 0.05).Post-operation 1.5 years survival rate of A group was obviously higher than C group, recurrence rate was lower than C group, comparative differences were statistically significant (P < 0.05).Post-operation 2 years survival rate of A group were significantly higher than B, C group Post-operation 2 years recurrence rate of A, B group were lower than C group ,compared with significant difference(P<0.05).The Pearson correlation analysis showed that the serum CEA level had negative correlation with survival rate (r = -3.536, P = 3.536), and had positively correlation with recurrence rate(r = 0.412, P = 0.412).Conclusion: The serum CEA levels has a close relationship with HCC prognosis.