外周血中血管内皮生长因子浓度变化对急性复发性脑梗死患者预后及神经功能康复的影响孙荣道,余丹,杨国帅海口市人民医院神经内科570208
Vascular endothelial growth factor concentration changes in peripheral blood of acute prognosis of patients with recurrent cerebral infarction and the influence of the neural function recovery

孙荣道.外周血中血管内皮生长因子浓度变化对急性复发性脑梗死患者预后及神经功能康复的影响孙荣道,余丹,杨国帅海口市人民医院神经内科570208[J].内科急危重症杂志,2017,23(1):

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作者	单位	E-mail
孙荣道	海口市人民医院	sunrong08dao@163.com

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中文摘要:

目的：探讨外周血中血管内皮生长因子浓度变化对急性复发性脑梗死患者预后及神经功能康复的影响。方法：选择我院2013年6月至2015年6月收治的80例急性复发性脑梗死患者,同期选择80例体检健康者,观察不同时间急性复发性脑梗死患者血清血管内皮生长因子(Vascular endothelial growth factor,VEGF)水平与梗死体积、神经功能康复、预后的关系。结果：急性复发性脑梗死组第1日、第3日、第7日血清VEGF水平均分别高于健康组,比较有明显差异(P<0.05)；梗死病灶体积≥2cm3组第1日、第3日、第7日血清VEGF水平均分别高于<2cm3组(P<0.05)；NIHSS<30分组第1日、第3日、第7日血清VEGF水平(172.65±20.18)ng/L、(237.64±28.59)ng/L、(283.35±37.42)ng/L均分别低于NIHSS≥30分组(252.30±29.67)ng/L、(346.81±40.54)ng/L、(459.67±48.23)ng/L,比较有显著差异(P<0.05)；预后良好组第1日、第3日、第7日血清VEGF水平(207.53±25.33)ng/L、(239.89±32.60)ng/L、(328.93±37.64)ng/L均分别低于预后不良组(275.65±28.11)ng/L、(316.80±41.07)ng/L、(459.64±52.27)ng/L,比较有明显差异(P<0.05)。结论：通过监测急性复发性脑梗死患者外周血中VEGF浓度变化,能够利于患者预后及神经功能康复的评估,血清VEGF水平越高患者预后及神经功能康复越差。

英文摘要:

objective: to study the vascular endothelial growth factor concentration changes in peripheral blood of acute prognosis of patients with recurrent cerebral infarction and neural functional recovery. Methods: 80 cases of acute recurrent cerebral infarction from June 2013 to June 2015 in ourShospital were treated, at the same time to choose 80 cases of healthy physical examination, to observe the different time of acute recurrent cerebral infarction patients serum vascular endothelial growth factor (VEGF) level and infarction volume and neurological rehabilitation, the relationship between the prognosis. Results: acute recurrent cerebral infarction group 1 day, 3 day, 7 day serum VEGF levels were higher than in healthy group respectively, with significant difference (P < 0.05); Infarction lesions≥2 cm3 group 1 day, 3 day7 daythe serum VEGF levels were higher than < 2 cm3 group (P < 0.05); NIHSS < 30 group 1 day, 3 day, 7 day serum VEGF levels (172.65±20.18) ng/L, (237.64±28.59) ng/L, (283.35±37.42) ng/L were respectively lower than ≥30NIHSS acuity group (252.30±29.67 ng/L, (346.81±40.54) ng/L, (459.67±48.23 ng/L, more significant differences (P < 0.05); Good prognosis group 1 day, 3 day,7day serum VEGF levels (207.53±25.33) ng/L, (239.89±32.60) ng/L, (328.93±37.64) ng/L were respectively lower than Poor prognosis group (275.65±28.11 ng/L,(316.80±41.07) ng/L, (459.64±52.27 ng/L, the more obvious difference (P < 0.05). Conclusion: by monitoring the VEGF concentration in peripheral blood of acute recurrent cerebral infarction patients, can be conducive to patient"s prognosis and neural function rehabilitation evaluation, the prognosis of patients with the higher the level of serum VEGF and neural function rehabilitation.