• 乌司他丁对脓毒症急性肾损伤患者尿NGAL、KIM-1、L-FABP水平的影响
  • Effect of ulinastatin on the level of NGAL, KIM-1and L-FABP of Urine in septic patients with acute kidney injury
  • 庞静,韩林,黄敏燕,蒋玲玉,熊滨,张静,莫丽.乌司他丁对脓毒症急性肾损伤患者尿NGAL、KIM-1、L-FABP水平的影响[J].内科急危重症杂志,2017,23(2):
    DOI:
    中文关键词:  乌司他丁  脓毒症  急性肾损伤
    英文关键词:
    基金项目:
    作者单位E-mail
    庞静 广西壮族自治区人民医院 重症医学科 gxgx980@163.com 
    韩林 广西壮族自治区人民医院 重症医学科  
    黄敏燕 广西壮族自治区人民医院 重症医学科  
    蒋玲玉 广西壮族自治区人民医院 重症医学科  
    熊滨 广西壮族自治区人民医院 重症医学科  
    张静 广西壮族自治区人民医院 重症医学科  
    莫丽 广西壮族自治区人民医院 重症医学科  
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    中文摘要:
          【】目的 探讨乌司他丁对脓毒症急性肾损伤患者尿中性粒细胞明胶酶相关脂运载蛋白(NGAL)、肾损伤分子-1(KIM-1)、肝型脂肪酸结合蛋白(L-FABP)表达水平的影响。方法 采用前瞻性研究,将2012年至2015年间在我科就诊的88例脓毒症合并急性肾损伤患者随机纳入对照组(常规治疗)或观察组(常规治疗 乌司他丁),每组44例,比较两组治疗前、治疗后3天、5天、7天患者尿液中NGAL、KIM-1及L-FABP水平,并比较两组患者急性生理与慢性健康评分Ⅱ(APACHEⅡ)及肾损伤程度。结果 两组患者NGAL、KIM-1及L-FABP水平在治疗前、治疗后3天、5天均升高,但观察组以上指标相对于对照组升高幅度较小,而在治疗后7天,观察组患者以上指标相对于对照组下降更显著,且两组间差异具有统计学意义(FNGAL=5.462,P<0.05; FKIM-1=3.674,P<0.05;FL-FABP=3.421,P<0.05);此外,治疗后观察组(14.93±1.08)与对照组(20.14±1.33)在 APACHEⅡ评分差异具有统计学意义,且观察组在治疗后5天及治疗后7天,患者肾损伤程度有所缓解。结论 乌司他丁可降低脓毒症急性肾损伤患者尿中NGAL、KIM-1及L-FABP水平,并有助于缓解肾脏损伤程度。
    英文摘要:
          【】 Objective To discuss effect of ulinastatin on the level of NGAL, KIM-1and L-FABP of Urine in septic patients with acute kidney injury. Methods A prospective study, the 88 cases of sepsis with acute kidney injury patients in our department from 2012 to 2015, they were randomly assigned control group (conventional treatment) or observation group (conventional therapy UTI), each group of 44 cases, comparison of two groups of patients NGAL, KIM-1 and L-FABP of urine before and after treatment 3 days, 5 days, 7 days, and comparison degree of renal injury and APACHEⅡof the two groups.Results Two groups of patients were increased NGAL, KIM-1 and L-FABP level at before treatment and after treatment, 3days, 5 days, the above observation group index increased to a lesser extent, but 7 days after treatment, the observation group were decreased more significantly, and the difference was statistically significant between the two groups(FNGAL=5.462,P<0.05; FKIM-1=3.674,P<0.05;FL-FABP=3.421,P<0.05);In addition, after treatment in the observation group (14.93 ± 1.08) and control group (20.14 ± 1.33) was statistically significant difference in APACHEⅡ score, and the observation group after treatment for 5 and 7 days after treatment, the severity of renal injury eased. Conclusion UTI can be reduced in patients with septic acute kidney injury in NGAL, KIM-1 and L-FABP of urine and help alleviate the degree of renal damage.