杨国涛,赵红英,董爱勤.高血尿酸水平作为急性卒中后抑郁发生的潜在防护因素可能性探讨[J].内科急危重症杂志,2017,23(5):
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| DOI： |
| 中文关键词: 急性卒中后抑郁 血清尿素 多因素Logistic回归 |
| 英文关键词:Post-stroke depression Serum uric acid Multiple logistical regression |
| 基金项目:沧州市科技计划项目（151302138） |
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| 中文摘要: |
| 目的 分析血尿酸水平与患者抑郁程度的相关性,初步探讨高血尿酸发挥潜在抑郁防护功效的可能性。方法 收集院内急性卒中后抑郁和非抑郁患者,统计临床基线资料并分为抑郁组和非抑郁组,比较两组患者血尿酸水平的差异；结合患者血尿酸的四分位数将抑郁患者分为25%组(<25%)、25-50%组、50-75%组、75%组(>75%)四组,检验四组患者的年龄、BMI指数、临床实验室数据、性别、心血管危险因子、神经功能评分之间的差异；比较不同抑郁程度患者血清尿酸水平并进行抑郁程度与血清尿酸水平相关性分析；logistic回归分析血尿酸对卒中后抑郁患者的影响。结果 共纳入抑郁患者73人,非抑郁患者231人；抑郁组与非抑郁组比较,非抑郁组的尿酸水平显著高于抑郁组(P<0.05)；年龄、性别、BMI、收缩压、舒张压、低密度脂蛋白(LDL)、血清肌酐(SCr)、血清尿酸(SUA)、NIHSS评分在各组之间的差异有统计学意义(P<0.05)；不同抑郁分组患者之间血尿酸水平差异有统计学意义(P<0.05),抑郁程度与血清尿酸水平存在负相关性(r=-0.247,P=0.000)；高血尿酸水平(>75%)是卒中后抑郁发生的防护因素(OR=0.247,P=0.004),低血尿酸水平(<25%)是卒中后抑郁发生的危险因素(OR=3.262,P=0.012)。结论 随着血清尿酸水平的升高,患者的抑郁程度逐渐降低,提示临床高血清尿酸水平的患者抑郁发生可能性较低。 |
| 英文摘要: |
| Objective To analyze correlation between serum uric acid and depression severity in patients with acute post-stroke depression and investigate possibility on potential preserve role of high uric acid. Methods Post-stroke patients were gathered in our hospital and their clinical baseline data was also collected; Patients were divided into two groups, including PSD and non- PSD group. Serum uric acid was compared test between two groups; Depression patients were also divided into four groups based on quartile of uric acid, 25% group(<25%), 25-50% group, 50-75% group, 75% group (>75%) included.Difference of patients’ age, BMI index ,clinical laboratory data, gender, cardiovascular risk factors and neurological functionamong four groups was tested; Serum uric acid in patients with disparate severity of depression was compared and correlation between uric acid level and depression severity was analyzed; Logistic regression was applied to analyze effect of serum uric acid on post-stroke depression.ResultsSeventy-three depression and two hundred and thirty-one non-depression patients were enrolled into this study; Uric acid in non-depression group was significantly higher than depression group (P<0.05); Difference of age, gender, BMI,SBP, DBP, LDL, SCr, SUA and NIHSS score in four groups had statistical significance (P<0.05); Serum uric acid difference among patients with various severity of depression had statistical significance (P<0.05). And correlation analysis showed significant negative correlation between uric acid and severity of depression of patients (r=-0.247, P=0.000); High serum uric acid was estimated to be a protect factor (OR=0.247,P=0.004) and low uric acid was a risk factor to post-stroke depression (OR=3.262,P=0.012). Conclusions Degree of depression in post-stroke patients alleviates gradually followed by elevated serum uric acid. High serum uric acid suggests a poor probability of depression occurrence. |
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