宋国智.神经节苷脂对弥漫性轴索损伤神经保护作用及其对血清NSE、S100B、MBP的影响[J].内科急危重症杂志,2017,23(5):
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| DOI： |
| 中文关键词: 弥漫性轴索损伤 神经节苷脂 神经保护 NSE S100B MBP |
| 英文关键词:Diffuse axonal injury Ganglioside Neuroprotective effect NSE S100B MBP |
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| 中文摘要: |
| 目的 分析神经节苷脂对弥漫性轴索损伤(DAI)神经保护作用及其对血清神经元特异性烯醇化酶(NSE)、S100B蛋白、髓鞘碱性蛋白(MBP)的影响。方法 按照入院顺序抽签后随机将80例DAI患者分为实验组和对照组,对照组患者给予常规综合治疗,实验组患者在此基础上加用神经节苷脂,比较两组患者疗程结束后3个月治疗结局、治疗前后血清MBP、S100B蛋白、NSE水平及GCS评分变化情况。结果 实验组患者治疗有效率显著高于对照组,差异有统计学意义(P＜0.05)；实验组患者治疗后3d、7d、14d血清NSE水平均显著低于对照组,差异有统计学意义(P＜0.05)；实验组患者治疗后3d、7d、14d血清S100B蛋白水平均显著低于对照组,差异有统计学意义(P＜0.05)；实验组患者治疗后3d、7d、14d血清MBP水平均显著低于对照组,差异有统计学意义(P＜0.05)；实验组患者治疗后7d、14d GCS评分均显著高于对照组,差异有统计学意义(P＜0.05)。结论 神经节苷脂能够有效改善DAI患者血清NSE、S100B蛋白、MBP水平,有明显的脑保护效果,可作为优选治疗药物。 |
| 英文摘要: |
| Objective To explore the influence of NSE, S100B, MBP and neuroprotective effect for the patients with diffuse axonal injury(DAI) by ganglioside. Methods 80 cases of patients with DAI were randomly divided into experiment group and control group. The control group were treated by routine combined therapy, the experiment group were treated by ganglioside based on the control group. The treatment outcome after 3 month and NSE, S100B, MBP, GCS scores before and after treatment were observed. Results The response rate for the experiment group were higher than the control group(P＜0.05); The NSE for the experiment group after 3d, 7d, 14d treatment were lower than the control group(P＜0.05); The S100B for the experiment group after 3d, 7d, 14d treatment were lower than the control group(P＜0.05); The MBP for the experiment group after 3d, 7d, 14d treatment were lower than the control group(P＜0.05); The GCS scores for the experiment group after 7d, 14d treatment were higher than the control group(P＜0.05). Conclusion It can improve the NSE, S100B and MBP for the patients with DAI. It has obvious neuroprotective effect. It can be the optimizing treatment. |
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