经鼻持续气道正压通气治疗重症AECOPD 对TNF-α、IL-6及IL-8的水平变化的研究
The study of nasal continuous positive airway pressure in patients with severe AECOPD to varying levels of TNF-α, IL-6 and IL-8

李俊.经鼻持续气道正压通气治疗重症AECOPD 对TNF-α、IL-6及IL-8的水平变化的研究[J].内科急危重症杂志,2017,23(4):

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英文关键词:nasal continuous positive airway pressure severe AECOPD inflammatory cytokines

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作者	单位	E-mail
李俊	珠海市人民医院	lijun6438@163.com

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中文摘要:

【】：目的：探讨经鼻持续气道正压通气治疗重症AECOPD对炎症因子变化的影响。方法：纳入2010年6月至2015年9月我院经鼻持续气道正压通气治疗重症AECOPD患者156例,分成两组,治疗组采用经鼻持续气道正压通气,对照组采用常规治疗。分别在治疗前、治疗48小时和结束治疗之后检测患者的TNF-α、IL-6及IL-8炎症因子表达水平,比较两组临床治疗情况,治疗前后血气分析、以及呼吸频率和心率等情况。结果：治疗前两组相比没有统计学差异(P>0.05)；治疗后治疗组患者炎症因子TNF-α、IL-6及IL-8较治疗前下降,对照组比较差异具有统计学意义(P<0.05)；治疗48小时两组分别于治疗前相比差异具有统计学意义,且两组间比较差异也具有统计学意义(P<0.05)；治疗后,两组差异有统计学意义(P<0.05),治疗组治疗后血气分析指标与治疗前相比,差异显著,对照组治疗前后PH无显著变化,而PaO2、PaCO2与治疗前相比,有明显差异。两组患者在并发症发生率、治疗时间、有效率方面差异有统计学意义。结论：经鼻持续气道正压通气可以改善重症AECOPD炎症因子水平,能够有效的缓解患者的临床症状,使患者血气分析指针以及生活质量得以改善。

英文摘要:

Objective: To investigate the effects of severe AECOPD changes of inflammatory factors of nasal continuous positive airway pressure therapy. Methods: Into my hospital in June 2010 to September 2015 period nasal continuous positive airway pressure in patients with severe AECOPD patients with 156 cases, divided into two groups, control group with conventional treatment group using nasal continuous positive airway pressure. Respectively, before treatment, 48 hours after the end of treatment and detection of patients with TNF-α, IL-6 and IL-8 expression of inflammatory cytokines levels were compared before and after treatment of blood gas analysis, clinical treatment and respiratory rate and heart rate, and so on. Results: No statistically significant difference compared to before treatment (P> 0.05); treatment 48 hours before treatment in the two groups were compared statistically significant difference, and the differences between the two groups was statistically significant (P <0.05 ); after treatment, patients treated with inflammatory cytokines TNF-α, IL-6 and IL-8 decreased compared with before treatment, the control group, the difference was statistically significant (P <0.05); after treatment, the difference was statistically significant ( P <0.05), PH in the control group no significant change compared, there are significant differences before PaO2, PaCO2 and treatment, blood gas analysis after treatment compared with before treatment, the difference was significant. Two groups in the incidence of complications, treatment time, there are statistically significant differences in terms of efficiency.Conclusion: The nasal continuous positive airway pressure can improve severe AECOPD levels of inflammatory factors, can effectively alleviate the clinical symptoms, blood gas analysis, and make the quality of life is improved.