姜维.联机血液透析滤过联合血液灌流对终末期肾病患者血压控制及CTGF、NT-ProBNP的影响[J].内科急危重症杂志,2017,23(5):
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| 中文关键词: 联机血液透析滤过 血液灌流 终末期肾病 血压控制 CTGF NT-ProBNP |
| 英文关键词:on-line hemedinfiltration hemoperfusion end-stage renal disease blood pressure control connective tissue growth factor N-terminal pro-brain B-type natriuretic peptides |
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| 中文摘要: |
| 【】目的 探讨联机血液透析滤过联合血液灌流对终末期肾病患者血压控制及CTGF(Connective Tissue Growth Factor,结缔组织生长因子)、NT-ProBNP(N-terminal pro-brain B-type natriuretic peptides ,N末端B型钠尿肽原)的影响。方法 选取2015年1月-2016年6月之间收入我院的60 例终末期肾病患者为研究对象,根据随机数字表发分为研究组和对照组,每组各30例,研究组患者给予联机血液透析滤过联合血液灌注(on-line HDF HP)治疗,对照组给予血液透析联合血液灌注(HD HP)治疗,比较两组患者的疗效、血压控制及CTGF、NT-ProBNP水平。结果 研究组患者的Kt/V值显著高于对照组(1.34±0.21 VS 1.06±0.10)(P<0.05)。治疗后,两组患者的SBP、DBP较治疗前均显著降低,且研究组显著低于对照组(P<0.05),研究组的血压控制达标,而对照组未达标。治疗后,两组患者的CTGF水平较治疗前均显著降低,且研究组显著低于对照组(P<0.05)。治疗后,两组患者的NT-ProBNP水平较治疗前均显著降低,且研究组显著低于对照组(P<0.05)。两组患者的不良反应无统计学意义(P＞0.05)。结论 联机血液透析滤过联合血液灌流对于治疗终末期肾病具有良好疗效,能够有效控制患者血压,降低CTGF、NT-ProBNP水平,值得推广应用。 |
| 英文摘要: |
| Objective To discuss the effect of on-line hemedinfiltration combined with hemoperfusion on blood pressure control and levels of CTGF; NT-ProBNP in patients with end-stage renal disease. Methods From January 2015 to June 2016, 60 patients with end-stage renal disease were selected for this study in our hospital and the patients were divided into two groups, study group and control group, 30 cases in each group. The study group was treated with on-line hemodialysis filtration combined hemoperfusion (on - line HDF HP) treatment, control group was treated with hemodialysis union blood perfusion (HD HP) treatment. The curative effect, blood pressure control and levels of CTGF; NT- ProBNP of two groups were compared. Results The Kt/V value of study group was significantly higher than the control group(1.34±0.21 VS 1.06±0.10)(P < 0.05). After treatment, the SBP, DBP of two groups were significantly reduced than before, and the study group was significantly lower than control group (P < 0.05), the study group was blood pressure control up to standard, the control group was not. After treatment, the levels of CTGF in two groups were significantly reduced than before, and the study group was significantly lower than control group (P < 0.05). After treatment, the levels of NT - ProBNP in two groups were significantly reduced than before, and the study group was significantly lower than control group (P < 0.05). The adverse reaction of three groups was no statistically significant difference (P > 0.05). Conclusion The application of on-line hemedinfiltration combined with hemoperfusion is effective for the patients with end-stage renal disease and it can effectively control blood pressure of patients, reduce the levels of CTGF; NT-ProBNP, it is worthy of clinical application. |
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