徐叶,田慧军.血清骨桥蛋白水平与急性脑出血患者病情及预后的关系[J].内科急危重症杂志,2017,23(3):
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| DOI： |
| 中文关键词: 脑出血 骨桥蛋白 预后 |
| 英文关键词:Cerebral hemorrhage Osteopontin Prognosis |
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| 中文摘要: |
| 目的 探讨血清骨桥蛋白(OPN)水平变化与急性脑出血患者病情严重程度及预后的关系。方法 选取急性脑出血患者46例作为观察组,入院后24h内进行NIHSS评分,根据CT计算脑出血体积,另选取同期健康体检者20例为对照组；采用ELISA法分别检测患者入院后1d、7d、14d以及对照组体检当日血清OPN水平,比较不同脑出血量、不同神经功能缺损严重程度患者血清OPN水平的差异；3个月后行改良Rankin量表(MRS)评分评价预后情况。根据MRS评分分为预后良好亚组(MRS评分＜3分)和预后不良亚组(MRS评分≥3分),采用Logistic回归分析影响预后的危险因素。结果 观察组患者血清OPN水平[(7.98±3.22)ng/mL]显著高于对照组[(4.08±2.15)ng/mL](t=5.366,P=0.000)；脑出血患者入院后1d、7d、14d血清OPN水平随着出血量的增大而逐渐增高(均P＜0.01)；入院后1d、7d、14d血清OPN水平随着神经功能缺损严重程度的加重而逐渐增高(均P＜0.01)；预后不良亚组年龄、hs-CRP、脑出血体积、NIHSS评分、血清OPN水平明显高于预后良好亚组(P＜0.05或0.01)；Logistic回归分析结果显示,入院时NIHSS评分、hs-CRP、OPN水平是影响脑出血患者预后的独立危险因素(均P＜0.05)。结论 脑出血患者血清OPN水平增高,与脑出血量、神经功能缺损严重程度有关,是预后不良的独立危险因素,可为脑出血患者预后判断提供一定的参考依据。 |
| 英文摘要: |
| Objective To explore the relationship between the change of serum osteopontin (OPN) levels and severity and prognosis in acute cerebral hemorrhage. Methods 46 patients with cerebral hemorrhage were selected as the observation group. The observation group was scored by NIHSS socre within 24h admission. According to CT, cerebral hemorrhage volume was calculated. 20 healthy individuals who underwent physical examination during the same period of time were selected as the control group. Serum OPN levels were determined by ELISA on day 1,day 7 and day 14 after admission respectively in the observation group and medical examination day in healthy control. The levels of serum OPN in the patients with different cerebral hemorrhage, with different neurological deficit were compared. All patients were scored at 3 months by modified Rankin scale (MRS) to evaluate the prognosis. According to MRS, all patients were divided into two subgroups: good prognosis subgroup (MRS＜3) and poor prognosis subgroup (MRS≥3). The risk factors that affect prognosis were analyzed by Logistic regression. Results The levels of serum OPN in the patients with cerebral hemorrhage [(7.98±3.22)ng/mL] were significantly higher than that of control group [(4.08±2.15)ng/mL](t=5.366,P=0.000). The gradually increasing of serum OPN levels was found on day 1,7,14 after admission which cerebral hemorrhage volume gradually increased (all P＜0.01).The gradually increasing of serum OPN levels was found on day 1,7,14 after admission which neurological deficit severity became gradually worse (all P＜0.01). Age,hs-CRP,cerebral hemorrhage volume,NIHSS score and OPN in the poor prognosis subgroup were significantly higher than those of good prognosis subgroup (P＜0.05 or 0.01);Logistic regression analysis showed that NIHSS at admission, hs-CRP and OPN were independent risk factors that influence the prognosis of patients with cerebral hemorrhage (all P＜0.05). Conclusions serum OPN levels in the patients with cerebral hemorrhage were increasing, which were associated with cerebral hemorrhage volume and neurological deficit severity. OPN is the independent risk factor for the poor prognosis. It can be used as a reference for the prognosis of cerebral hemorrhage. |
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