无针注射器与诺和笔皮下注射胰岛素控制糖尿病患者血糖的交叉对照研究
A comparative study of the effects of needle free versus insulin pen injection on glycemia controlling in diabetic patientsLv Lingbo, Chen Yuhua, Chi Lianxiang, Tian Feng, Lu Zeyuan, Yan Dewen*

吕凌波,阎德文.无针注射器与诺和笔皮下注射胰岛素控制糖尿病患者血糖的交叉对照研究[J].内科急危重症杂志,2017,23(3):

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英文关键词:Diabetes mellitus Needle-free injection system Insulin

基金项目:深圳市科技计划项目[编号：JCYJ20130401112026994]

作者	单位	E-mail
吕凌波	深圳市第二人民医院	lvlingbo@126.com
阎德文	深圳市第二人民医院	yandw963@126.com

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中文摘要:

目的：观察无针注射器(QS-M)和诺和笔皮下注射胰岛素对糖尿病患者血糖控制的影响。方法 20例诺和锐30胰岛素治疗稳定的糖尿病患者随机交叉分组,采用无针注射器和诺和笔皮下注射胰岛素,比较两种注射方式对指尖血糖、糖化血红蛋白及糖化血清蛋白的影响。受试者填写疼痛感受量表以评估注射体验。结果两种注射方式比较,糖化血红蛋白、糖化血清蛋白及各时段指尖血糖差异无显著性(P>0.05)；年龄≥50岁的患者,无针注射器组各时段指尖血糖均高于诺和笔组,其中早餐后2小时血糖(P=0.003)及中餐前血糖(P=0.006)有显著性差异；年轻患者使用无针注射器后各时段指尖血糖低于诺和笔组,差异无统计学意义(P>0.05)。15名受试者(75%)使用无针注射器疼痛感明显减轻,且均未出现硬结现象。结论无针注射器注射胰岛素控制血糖效果肯定,而且有自身的优点：痛感明显减轻，携带方便，不会产生皮下硬结。

英文摘要:

Objective To evaluate the effect of the needle-free injection system (QS-M) and insulin pen on glycemia controlling in the diabetic patients. Methods A total of 20 patients with diabetes mellitus subjected to Novomix 30 insulin therapy were enrolled in the study. A comparison study was carried out in these subjects treated by the QS-M and insulin pen. Glycosylated hemoglobin (HbA1c), glycated serum protein (GSP) and Blood glucoses were measured at certain time. At the end of the study, all subjects answered the questionnaire designed for assessing their experiences. Results No difference was shown in HbA1c, GSP and seven-point finger blood glucoses between two injection modes. Finger blood glucoses of the subjects over 50 years old measured at all the time points appeared to be higher for the QS-M injection than that for insulin pen injection. But the significant difference was only found for finger blood glucoses at 2 h after breakfast and pre-lunch (P = 0.003 and 0.006, respectively). All measured finger blood glucoses appeared to be lower for the QS-M injection than that for insulin pen injection in the subjects younger than 50 years old, but the difference was not statistically significant. Fifteen subjects (75%) subjected to insulin pen injection felt significant less pain than those subjected to QS-M injection, and no cases developed subcutaneous scleroma for QS-M injection. Conclusion The QS-M injection is effective in lowering blood sugar level, and shows its own advantages in treating diabetic patients, such as less pain, portable and no subcutaneous scleroma.