孟详喻,何莉.儿童肿瘤患者口服靶向药后胃肠不良反应发生率的meta分析[J].内科急危重症杂志,2017,23(5):
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| DOI： |
| 中文关键词: 儿童 肿瘤 口服靶向药物 胃肠不良反应 meta分析 |
| 英文关键词:Pediatric Cancer Oral targeted agents Gastrointestinal adverse reaction Meta-analysis |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）（基金号：81272627）, |
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| 中文摘要: |
| 目的：对儿童肿瘤患者口服靶向药后胃肠不良反的应事件率进行meta分析。方法：在 Pubmed文献数据库中检索相关文献。根据纳入与排除标准筛选纳入研究并进行质量评价。提取基本情况与胃肠不良反应事件率数据，logit转换后进行meta分析。结果：本研究共纳入13项临床试验。除厌食外，其他结局meta分析有显著异质性。腹泻合并发生率及其95%CI为0.20[0.13-0.28]，恶心为0.19[0.14-0.26]，呕吐为0.17[0.12-0.24]，厌食为0.06[0.04-0.11]。结论：儿童肿瘤患者在接受口服靶向抗肿瘤药物治疗后可能出现胃肠不良反应，临床应用时应充分认识并监测。 |
| 英文摘要: |
| OBJECTIVE：To perform a meta-analysis on the rate of gastrointestinal adverse reactions after oral targeted agents in pediatric cancer patients. METHODS：The Pubmed database was searched for relevant articles. Eligible studies were selected according to predefined inclusion and exclusion criteria, the quality of which was evaluated. Basic information and gastrointesitnal adverse event rate data were extracted, and meta-analysis was conducted after logit transformation. RESULTS: A total of 13 trials were included. Significant heterogeneity was found for diarrhea, nausea and vomiting. Pooled event rate and its 95% confidence interval is 0.20[0.13-0.28], 0.19[0.14-0.26], 0.17[0.12-0.24], and 0.06[0.04-0.11], respectively for diarrhea, nausea, vomiting, and anorexia. CONCLUSIONS: Gastrointestinal adverse events may happen in pediatric cancer patients after oral targeted therapy, and close monitoring and preparation is important. |
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