赵淑芬.中晚期肝癌患者肝动脉化疗栓塞术后肝功能代偿不全影响因素分析[J].内科急危重症杂志,2019,25(1):19-20
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| DOI：10.11768/nkjwzzzz20190105 |
| 中文关键词: 原发性肝癌 经肝动脉化疗栓塞 中晚期肝癌 肝功能储备 肝功能代偿不全 |
| 英文关键词: |
| 基金项目:佛山市自筹经费类科技计划项目 （No：2016AB003473）;佛山市十三五高水平重点专科建设项 |
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| 中文摘要: |
| 目的：分析中晚期原发性肝癌（HCC）首次行肝动脉化疗栓塞术（TACE）后出现肝功能代偿不全的影响因素。方法：回顾性分析103例中晚期HCC首次行TACE术患者的临床资料，根据其术后是否发生肝功能代偿不全分为2组，对2组患者术前、术后相关临床数据进行单因素与多因素分析，找出影响患者术后出现肝功能代偿不全的主要因素。结果：单因素分析显示，术前患者吸烟、年龄、门脉Ⅱ级主干癌栓、乙肝、凝血酶原时间、D-二聚体、谷氨酰转肽酶（GGT）水平、肿瘤大小均是首次TACE术后出现肝功能代偿不全的影响因素（均P<0.05）；多因素logistic回归分析显示，年龄、血凝血酶原时间、D-二聚体、GGT、肿瘤大小是首次TACE术后出现肝功能代偿不全的危险因素（均P<0.05）。结论：高龄、肿瘤较大、凝血酶原时间、D-二聚体、GGT升高的中晚期HCC患者行TACE术后出现肝功能代偿不全的风险高。 |
| 英文摘要: |
| Objective: To analyze the influencing factors of compensatory insufficiency of liver function in patients with advanced primary hepatocellular carcinoma (HCC) for the first time after transcatheter arterial chemoembolization (TACE). Methods: A total of 103 patients with primary advanced HCC who underwent TACE for treatment were reviewed, and divided into two arms according to whether insufficiency of liver function was developed after TACE. Univariate and multivariate analyses were performed on the clinical data before and after TACE to screen the main factors influencing postoperative insufficiency of liver function. Results: Univariate analysis showed that smoking, age, main portal vein (Tpye Ⅱ) tumor thrombus, hepatitis B infection status, prothrombin time, D-dimer, GGT level and main tumor size before TACE were the influencing factors of compensatory insufficiency of liver function after the first time of TACE (P<0.05). Multivariate logistic regression analysis showed that age, prothrombin time, D-dimer and GGT and tumor size were the influencing factors of compensatory insufficiency of liver function after the first time of TACE (P<0.05). Conclusion: Advanced age, larger tumor size, prothrombin time, D-dimer and elevated GGT increased the risk of compensatory insufficiency of liver function in patients with advanced HCC after TACE. |
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