重症肺部感染患者外周血调节性T淋巴细胞、白介素10水平与甲泼尼龙疗效的关系
Relationship between peripheral blood Treg and IL-10 levels with efficacy of methylprednisolone in patients with severe pulmonary infection

黄青.重症肺部感染患者外周血调节性T淋巴细胞、白介素10水平与甲泼尼龙疗效的关系[J].内科急危重症杂志,2019,25(1):48-49

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DOI：10.11768/nkjwzzzz20190115

中文关键词: CD4+CD25+调节性T淋巴细胞白介素10 甲泼尼龙重症肺部感染疗效

英文关键词:

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作者	单位	E-mail
黄青	枣庄矿业集团中心医院	1173930514@qq.com

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中文摘要:

目的：探讨重症肺部感染（SPI）患者外周血CD4+CD25+调节性T淋巴细胞（Treg）、白介素10（IL-10）水平与甲泼尼龙疗效的关系。方法：选取SPI患者100例作为SPI组，均给予对症治疗和甲泼尼龙治疗，同期选取体检中心健康人员30例作为健康组。结果：SPI组外周血Treg、IL-10水平明显低于健康组（均P<0.05）；治疗后，SPI组显效72例（72.0%）、有效20例（20.0%）、无效8例（8.0%）；治疗后，显效和有效患者外周血Treg、IL-10水平较治疗前上升（均P<0.05），且显效患者外周血Treg、IL-10水平上升值明显高于有效患者（P<0.05）。结论：外周血Treg、IL-10水平与SPI的发生和转归有关，其水平变化可作为评估甲泼尼龙治疗SPI疗效的重要指标。

英文摘要:

Objective: To discuss the relationship between the peripheral blood CD4 + CD25 + regulatory T lymphocytes (Treg) and interleukin-10 (IL-10) level with efficacy of methylprednisolone in patients with severe pulmonary infection (SPI). Methods: 100 patients with SPI were selected as SPI group, and 30 health persons were selected as healthy group at the same time from the Medical Examination Center. Results: The peripheral blood Treg and IL-10 levels in SPI group were significantly lower than those in healthy group (P< 0.05). After the treatment, 72 cases were excellent (72.00%), 20 cases were valid (20.00%) and 8 cases were invalid (8.00%) in SPI group, and the peripheral blood Treg and IL-10 levels in the patients with excellent and valid efficacy were significantly increased as compared with those before treatment (P<0.05). The peripheral blood Treg and IL-10 levels in the invalid patients before and after treatment showed no statistically significant difference (P>0.05). The increased values of peripheral blood Treg and IL-10 levels in the excellent patients were significantly higher than those in the valid patients, and those in the valid patients were significantly higher than those in the invalid patients (all P<0.05). Conclusions: The peripheral blood Treg and IL-10 levels are related to the occurrence and outcome of SPI. The changes in peripheral blood Treg and IL-10 levels can be used as an important index to evaluate the efficacy of methylprednisone in the treatment of SPI.