血钙、D-二聚体、血糖对高甘油三酯血症性急性胰腺炎预后的影响
Effect of serum calcium, D-dimer and glucose on prognosis of hyperlipidemic acute pancreatitis

安铁峰.血钙、D-二聚体、血糖对高甘油三酯血症性急性胰腺炎预后的影响[J].内科急危重症杂志,2019,25(3):213-215

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DOI：10.11768/nkjwzzzz20190311

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作者	单位	E-mail
安铁峰	北京市垂杨柳医院	antieshengys@163.com

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中文摘要:

目的：观察高甘油三酯血症性急性胰腺炎（HLAP）患者血钙、D-二聚体、血糖水平的变化，探讨其与疾病严重程度及预后的关系。方法：选择急性胰腺炎（AP）患者366例，其中76例患者为HLAP。另外选择60例健康志愿者作为对照组。根据疾病严重程度，将HLAP患者分为轻症和重症患者。测定患者血甘油三酯（TG）、血钙、D-二聚体和血糖水平，并计算24h急性生理与慢性健康状况(APACHEⅡ)评分和48h急性胰腺炎预后因素(Ranson)评分，评估对HLAP患者疾病严重程度和预后的影响。结果： HLAP组患者24hAPACHEⅡ评分和48hRanson评分明显高于非HLAP组患者（P<0.05）。HLAP组患者血糖、血钙、D-二聚体水平分别为(13.03±5.22)mmol/L、(2.02±0.37)mmol/L、(2.34±1.45)mg/L，与非HLAP组患者比较，差异有统计学意义（P<0.05）。且HLAP组患者病情越严重，TG水平、血糖和D-二聚体水平越高，血钙水平越低（P<0.05）。结论： HLAP患者进行血糖、血钙和D-二聚体水平检测，有助于对患者疾病严重程度和预后进行判断。

英文摘要:

Objective: To observe the changes of the serum calcium, D-dimer and glucose in the patients with hyperlipidemic acute pancreatitis (HLAP), and investigate their correlation with the severity and prognosis of HLAP. Methods: 366 cases of AP were enrolled in this study, and divided into the non-HLAP group (290 cases) and the HLAP group (76 cases). Besides, 60 health volunteers were chosen as the health control group. According to the severity of HLAP, the HLAP patients were classified into mild group and severe group. The serum levels of triglyceride (TG), calcium, D-dimer and glucose were determined by routine laboratory test. Meanwhile, 24h APACHEⅡscores and 48h Ranson scores were recorded. The relationship between the prognosis of HLAP and the serum calcium, D-dimer or glucose levels was analyzed. Results: The serum level of TG in HLAP group was obviously higher than that in non-HLAP group (P<0.01. The serum levels of glucose, calcium and d-dimer in the HLAP group were (13.03±5.22) mmol/L, (2.02±0.37) mmol/L and (2.34±1.45) mg/L respectively, which were significantly different from those in the NHLAP group (all P<0.05).The 24h APACHEⅡ scores and 48h Ranson scores in the HLAP group were significantly higher than in the non-HLAP group (both P<0.05). The more severe the HLAP was, the higher the levels of TG, glucose and D-dimer were, and the lower the serum level of calcium was. Conclusion: The detections of the serum levels of calcium, D-dimer and glucose could help evaluate the prognosis and severity of HLAP.