姜利军.应用抗PD-1抗体治疗恶性淋巴瘤致少见不良反应的临床报告[J].内科急危重症杂志,2019,25(5):370-373
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| DOI：10.11768/nkjwzzzz20190505 |
| 中文关键词: 抗PD-1抗体 不良反应 |
| 英文关键词:Severe acute pancreatitis Ulinastatin Octreotide Inflammatory response |
| 基金项目:国家自然基金科学基金（No：81300410、81873444） |
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| 中文摘要: |
| 目的：探讨抗PD-1抗体治疗恶性淋巴瘤导致的少见不良反应。 方法： 收集使用过抗PD-1抗体的肿瘤患者的临床资料，分析这些患者发生不良反应的情况，从中筛选出少见的不良反应病例。 结果： 华中科技大学同济医学院附属同济医院3年间有157例肿瘤患者使用抗PD-1抗体治疗，大部分不良反应较轻无需治疗，其中4例患者发生少见不良反应，分别为免疫性脑炎、心肌炎、垂体功能紊乱和间质性肺炎。通过复习文献，考虑上述不良反应为抗PD-1抗体所致的免疫相关不良反应。 结论：临床工作中需要警惕抗PD-1抗体可能导致的少见不良反应，尽早诊断和治疗，将不良反应的危害降至最低。 |
| 英文摘要: |
| Objective To discuss the rare adverse effects caused by anti-PD-1 antibody in patients with malignant lymphomas. Methods: The clinical data of the patients who had received anti-PD-1 antibody treatment were collected, and the adverse events were analyzed. Patients with rare adverse events were selected. Results: 157 patients had received anti-PD-1 antibody treatment during the 3 years. Most adverse events were mild that didn't need any treatment. However, 4 patients suffered from rare adverse events, including autoimmune encephalitis, myocarditis, pituitary malfunction and interstitial pneumonia, respectively. These adverse events were considered as immune-related adverse events caused by anti-PD-1 antibody. Conclusion: Clinical doctors must pay attention to rare adverse events caused by anti-PD-1 antibody. The diagnosis and treatment should be given as soon as possible, so as to minimize the damage to patients. |
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