急性胰腺炎患者血浆硫化氢、Apelin-36水平与血栓弹力图参数及病情严重程度的关系
Relationship between plasma hydrogen sulfide and Apelin-36 levels and thrombelastogram parameters, severity of disease in patients with acute pancreatitis

侯婷婷.急性胰腺炎患者血浆硫化氢、Apelin-36水平与血栓弹力图参数及病情严重程度的关系[J].内科急危重症杂志,2019,25(5):374-377

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DOI：10.11768/nkjwzzzz20190506

中文关键词: 急性胰腺炎硫化氢 Apelin-36 血栓弹力图参数病情相关性

英文关键词:Coronary artery disease VSTM1 Coronary angiography Gensini score Acute myocardial infarction

基金项目:济南市科技计划（医疗卫生）项目（No：2014Jnkj13）

作者	单位	E-mail
侯婷婷	山东大学附属省立医院	270297962@qq.com

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中文摘要:

目的: 分析急性胰腺炎（AP）患者血浆硫化氢（H2S）、Apelin-36水平与血栓弹力图参数及病情严重程度的关系。方法: 选取AP患者80例，根据病情严重程度分为轻症急性胰腺炎（MAP）组45例和重症急性胰腺炎（SAP）组35例。另选取同期体检的健康志愿者30例作为对照组。比较3组受试者血浆H2S、Apelin-36水平、急性生理与慢性健康状况评分Ⅱ（APACHEⅡ）、血栓弹力图参数，分析其相关性。结果：SAP组血浆H2S、Apelin-36水平及APACHEⅡ评分均高于MAP组和对照组，且MAP组高于对照组（均P<0.05）；SAP组的最大振幅（MA）值、凝血块强度（G）值均高于MAP组和对照组，凝固角（α）较对照组大（均P<0.05），MAP组的α角、MA值、G值较对照组大（均P<0.05）；AP患者血浆H2S水平与血凝时间（R）值、血块成型时间（K）值、Apelin-36无明显的相关性（P>0.05），与α角、MA值、G值、APACHEⅡ评分呈正相关（P<0.05）；血浆Apelin-36水平与R值、K值、α角、MA值、G值均无明显的相关性（P>0.05），与APACHEⅡ评分呈正相关（P<0.05）。结论： AP患者存在一定的凝血功能障碍，血浆H2S、Apelin-36水平明显升高，并与患者的病情严重程度密切相关，其中H2S水平与血栓弹力图部分参数存在一定的相关性。

英文摘要:

Objective: To analyze the relationship between plasma hydrogen sulfide (H2S) and Apelin-36 levels and thromboelastogram parameters, severity of acute pancreatitis (AP). Methods: Eighty patients with AP were selected as the research subjects. According to the severity of the disease , the patients were divided into mild AP (MAP) group (45 cases) and severe AP (SAP) group (35 cases). Thirty healthy volunteers undergoing medical tests in our hospital during the same period were selected as control group. Plasma H2S, Apelin-36 levels, acute physiology and chronic health score (APACHE II), thrombelastogram parameters in three groups were compared, and the correlation was analyzed. Results: The levels of plasma H2S, Apelin-36 and APACHE II score in SAP group were higher than those in MAP group and the control group, and those in the MAP group was higher than in the control group (all P<0.05). The values of maximal amplitude (MA) and blood clot intensity (G) in SAP group were greater than those in MAP group and control group, the coagulation angle (α) was larger than that in control group (all P<0.05). The α angle, MA value, G value in MAP group were greater than those in the control group (all P<0.05). There was no significant correlation between the level of plasma H2S and blood coagulation time (R) value, blood clotting time (K) value and Apelin-36 in patients with AP (P>0.05), and there was a positive correlation between the level of plasma H2S and α angle, MA value, G value and APACHE II score (P<0.05). There was no significant correlation between plasma Apelin-36 level and R value, K value, α angle, MA value and G value (P>0.05), and there was a positive correlation between the level of plasma H2S and APACHE II score (P<0.05). Conclusion: There is a certain coagulation dysfunction in patients with AP. The levels of plasma H2 and Apelin-36 are high in the patients with AP, and they are closely related to the severity of the patient's condition. There is a certain correlation between the level of H2S and some parameters of thrombelastogram.