单核细胞表面受体VSTM1与冠状动脉粥样硬化及斑块稳定性的关系
Relationship between VSTM1 and coronary atherosclerosis and plaque stability

王晓菲.单核细胞表面受体VSTM1与冠状动脉粥样硬化及斑块稳定性的关系[J].内科急危重症杂志,2019,25(5):381-383

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DOI：10.11768/nkjwzzzz20190508

中文关键词: 冠状动脉疾病 VSTM1 冠状动脉造影术 Gensini积分急性心肌梗死

英文关键词:Heart failure Hemodialysis Lung comets

基金项目:国家自然科学基金（No：81470546）

作者	单位	E-mail
王晓菲	上海交通大学医学院附属第九人民医院	changqianwang@hotmail.com

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中文摘要:

目的：探讨单核细胞表面VSTM1的表达水平与冠状动脉病变的相关性及临床意义。方法：选择确诊或疑诊冠心病而行冠状动脉造影检查的患者121例，依据患者冠状动脉造影检查结果，将入选者分为对照组和实验组。对照组为冠脉造影堵塞<50％者；实验组为冠脉造影堵塞≥50％者；实验组根据临床症状分为不稳定型心绞痛、稳定型心绞痛以及急性心肌梗死组，根据病变情况又分为单支、两支及三支病变组。比较各组VSTM1水平，并计算Gensini积分，探讨VSTM1水平与 Gensini积分和病变支数的关系。结果：①急性心肌梗死组和不稳定型心绞痛组的VSTM1水平显著低于稳定型心绞痛组和对照组(均P<0.05)。②单支、双支及三支病变组间的VSTM1水平比较，差异无统计学意义。③VSTM1水平与冠状动脉Gensini评分无明显相关关系（R=0.15）。结论: 单核细胞表面VSTM1表达的降低可能与动脉粥样硬化斑块的不稳定性有关，动态监测单核细胞表面VSTM1表达水平对预测冠状动脉病变进展具有较好的临床价值。

英文摘要:

Objective: To investigate the correlation between the expression of VSTM1 on monocyte surface and coronary artery disease and its clinical significance. Method: 121 consecutive patients with confirmed or suspected coronary heart disease undergoing coronary angiography were enrolled in this study. All patients were divided into control group and experimental group according to the results of coronary angiography. The control group was divided into unstable angina pectoris, stable angina pectoris and acute myocardial infarction subgroups according to clinical symptoms. The experimental group was divided into single vessel, two vessel and three vessel lesions sbugroups according to the results of coronary angiography. The levels of VSTM1 in each group were measured, and the Gensini score was calculated to explore the relationship between the levels of VSTM1 and the Gensini score and the number of lesions in each group. Results: ①VSTM1 levels in acute myocardial infarction subgroup and unstable angina subgroup were significantly lower than those in stable angina subgroup and control group (P<0.05). ②There was significant difference in the expression of VSTM1 between the two-vessel lesion subgroup and control group (P<0.05). ③There was no significant correlation between VSTM1 level and Gensini score (R=0.15). Conclusion: The decrease of VSTM1 expression on monocyte surface may be related to the instability of atherosclerotic plaque. Dynamically monitoring the expression of VSTM1 on monocyte surface has good clinical value in predicting the progression of coronary artery disease.