冠状动脉粥样硬化心脏病患者外周血中血小板miR-126水平及临床意义
Correlation between peripheral blood platelet miR-126 expression and coronary arteriosclerosis disease

王阳.冠状动脉粥样硬化心脏病患者外周血中血小板miR-126水平及临床意义[J].内科急危重症杂志,2019,25(5):384-386

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DOI：10.11768/nkjwzzzz20190509

中文关键词: miR-126 冠状动脉粥样硬化性心脏病稳定型心绞痛急性冠状动脉综合征

英文关键词:Platelet microparticles Acute coronary syndrome Risk degree Prognosis

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作者	单位	E-mail
王阳	沈阳市第四人民医院	58837999@qq.com

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中文摘要:

目的：探讨外周血中血小板miR-126水平在冠心病诊断、预测及预后分析中的应用价值。方法：选取冠心病患者80例为冠心病组，包括稳定型心绞痛 (SAP)组及急性冠状动脉综合征 (ACS)组各40例,选择同期健康体检者40例作为健康对照（NC）组，qRT-PCR检测3组患者血小板miR-126表达，比较其在3组患者中表达水平的差异，分析miR-126与冠脉斑块CT值分型的关系，比较miR-126在不同冠脉造影病变程度、分型及病变支数中表达水平的差异。结果：ACS组及SAP组miR-126表达高于NC组（P<0.01），且ACS组高于SAP组（P<0.05）；在冠脉斑块CT值分型中，钙化型miR-126表达水平高于纤维型及软质型，且纤维型高于软质型（P<0.05）；中度、重度及闭塞组miR-126表达水平高于轻度组（P<0.05），且重度及闭塞组高于中度组（P<0.05）；在2支及≥3支病变组miR-126表达水平高于1支病变组（P<0.05），≥3支病变组高于2支病变组（P<0.05）。结论：在不同冠状动脉粥样硬化严重程度中，血小板miR-126表达水平不同，miR-126表达高者冠状动脉病变程度及支数均较高。

英文摘要:

Objective: To observe the correlation between miR-126 expression and coronary arteriosclerosis disease, and discuss the value of miR-126 in diagnosis, forecast and prognosis of coronary heart disease (CHD). Methods: Eighty patients diagnosed as CHD were divided into stable angina pectoris (SAP) group (n=40) and acute coronary arterial syndrome (ACS) group (n=40). Forty healthy people selected from physical examination center served as control group (NC group). QRT-PCR was used to detect the platelet miR-126 expression in all three groups. The correlation between miR-126 expression and coronary plaque CT value type, coronary angiography degree and pathological arterial numbers was evaluated. Results: The expression of miR-126 in ACS group and SAP group was significantly higher than in NC group (P<0.01), and that in ACS group was significantly higher than in SAP group (P<0.05). The expression of miR-126 in calcium type group was significantly higher than in fibrosis type group and soft type group, and that in fibrosis type group was significantly higher than in soft type group (P<0.05). The expression of miR-126 in median, serious and occlusion groups was significantly higher than in mild group (P<0.05), and that in serious and occlusion groups was significantly higher than in median group (P<0.05). The expression of miR-126 in 2 and ≥3 branches groups was significantly higher than in 1 branch group (P<0.05). Conclusions: Platelet miR-126 expression is various in different degrees of coronary arteriosclerosis, and miR-126 expression was high in serious coronary pathological changes and much branches.