高血压病合并不同类型脑小血管病与认知功能障碍的关系
Relationship between hypertension with different types of cerebral small vessel disease and cognitive impairment

李姣等.高血压病合并不同类型脑小血管病与认知功能障碍的关系[J].内科急危重症杂志,2020,26(3):191-193

扫码阅读全文

DOI：10.11768/nkjwzzzz20200304

中文关键词: 高血压病脑小血管病认知功能障碍腔隙性脑梗死脑白质变性脑微出血痴呆

英文关键词:

基金项目:国家自然科学基金面上项目（No:81974218、No:81671064、No:81371222）

作者	单位	E-mail
李姣等	武汉市汉口医院等	：wangfurong.china@163.com

摘要点击次数: 2037

全文下载次数: 3185

中文摘要:

目的：探讨高血压病合并不同类型脑小血管病（CSVD）与认知功能障碍的关系，及其可能机制。方法：收集168例高血压病合并CSVD住院患者的临床资料，CSVD分为腔隙性脑梗死、脑白质变性和脑微出血3种类型。根据其（VCI）程度将患者分为无VCI(NVCI)组(99例)和非痴呆性VCI(VCIND)组(69例) ，比较2组病例简易精神状态量表（MMSE）评分的差异，并检测2组患者血清白介素1（IL-1）、IL-6、IL-10及高迁移率族蛋白（HMGB1）的水平，研究其发病机制。结果：VCIND组MMSE评分明显低于NVCI 组[（16.20±3.35) 分 vs ( 29.40±5.74) 分，t=13.650，P＜0.05）]；而各组内3种不同类型CSVD MMSE评分比较，差异无统计学意义(均P＞0.05) 。与NVCI 组比较，VCIND组血清IL-1、IL-6、HMGB1水平显著升高(均P＜0.05) ，而IL-10水平比较差异无统计学意义（P＞0.05）。结论：高血压病合并不同类型CSVD人群发生VCIND可能与高细胞炎症反应相关。

英文摘要:

Objective: To investigate the relationship between hypertension with different types of cerebral small vessel disease (CSVD) and cognitive impairment and the possible mechanism. Methods: Clinical data of 168 patients diagnosed with hypertension complicated with CSVD were collected, and divided into three types: lacunar cerebral infarction, white matter degeneration and cerebral microbleeds. According to the degree of the vascular cognitive impairment (VCI), the patients were divided into the non-VCI (NVCI) group (99 cases) and the non-dementia VCI (VCIND) group (69 cases). The difference in the MMSE score between two groups was compared. Serum levels of inflammatory cytokines \[interleukin-IL-1, IL-6, IL-10, and high-mobility group protein 1 (HMGB1)\] in the two groups were determined to investigate the pathogenesis. Results: MMSE score in VCIND group was significantly lower than that in NVCI group \[(16.20±3.35) vs (29.40±5.74), t =13.650, P <0. 05)\]. There was no difference in MMSE scores among three types of CSVD in two groups (all P >0. 05). The levels of IL-1, IL-6 and HMGB1 in the VCIND group were significantly higher than those in the NVCI group (all P <0. 05), while the level of IL-10 in the two groups showed no significant difference ( P >0.05). Conclusion: The occurrence of VCIND in hypertensive patients with different types of CSVD might be related to the hypercellular inflammatory response.