血清单核细胞趋化蛋白-1在间质性肺疾病诊断中的价值
Value of serum monocyte chemoattractant protein-1 in the diagnosis of interstitial lung disease

段迎晓.血清单核细胞趋化蛋白-1在间质性肺疾病诊断中的价值[J].内科急危重症杂志,2021,27(2):129-130

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DOI：10.11768/nkjwzzzz20210210

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作者	单位	E-mail
段迎晓	海南省文昌市人民医院	duanyinx25@163.com

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中文摘要:

目的：探讨血清单核细胞趋化蛋白-1(MCP-1)在间质性肺疾病（ILD）诊断中的临床价值。方法：随机选取80例ILD患者为病例组，同期80例非吸烟的健康体检者为对照组。比较2组患者血清MCP-1水平，同时测定白细胞介素-18(IL-18)、C反应蛋白(CRP) 水平及肺功能指标，采用Pearson方法进行相关性分析。结果:对照组血清MCP-1、IL-18及CRP水平低于病例组，第一秒钟用力呼气容积(FEV-1)、肺一氧化碳弥散量(DLCO)、用力肺活量（FVC）高于病例组（均 P ＜0.01)。ILD患者血清MCP-1与IL-18及CRP呈正相关( r=0.653，r=0.712，均P < 0.05)，与FEV-1、DLCO、FVC呈负相关( r=-0.581，r=-0.523，r =-0.554，均 P ＜0.05)。结论：ILD患者血清 MCP-1水平升高可能与其气道炎症和气流受限有关，在诊断ILD中具有一定的临床价值。

英文摘要:

Objective: To explore the clinical value of serum monocyte chemoattractant protein-1 (MCP-1) in the diagnosis of interstitial lung disease (ILD). Methods: Totally, 80 patients with ILD were randomly selected as the case group, and 80 non-smokers in the same period were selected as the control group. Interleukin-18 (IL-18), C-reactive protein (CRP) levels and pulmonary function indexes were measured and compared. The data were analyzed by SPSS20.0 software. Results: Serum levels of MCP-1, IL-18 and CRP in the control group were significantly lower than those in the patients with ILD, FEV-1 and DLCO in the control group were significantly higher than those in the case group (all P <0.01). Serum MCP-1 in patients with ILD was positively correlated with IL-18 and CRP ( r=0.653, r=0.712, P < 0.05), negatively correlated with FEV-1 and DLCO ( r=-0.581, r=-0.523, r=-0.554, P <0.05). Conclusion: As one of the inflammatory markers in patients with ILD, MCP-1 is associated with airway inflammation and airflow limitation. It has certain clinical application value in the diagnosis of ILD.