• 布地奈德混悬液联合胸腺肽α1减少老年气管切开患者肺部感染
  • 张新峰.布地奈德混悬液联合胸腺肽α1减少老年气管切开患者肺部感染[J].内科急危重症杂志,2021,27(6):477-479
    DOI:10.11768/nkjwzzzz20210608
    中文关键词:  布地奈德  胸腺肽α1  老年人  气管切开  肺部感染
    英文关键词:
    基金项目:
    作者单位E-mail
    张新峰 首都医科大学附属北京康复医院老年康复中心 scaiclm@163.com 
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    中文摘要:
          摘要 目的:探讨布地奈德混悬液联合胸腺肽α1对老年气管切开患者肺部感染的预防作用。方法:回顾性分析2017年10月 2018年10月首都医科大学附属北京康复医院收治的98例老年气管切开患者的临床资料,按照不同治疗方法分为A组(胸腺肽α1)和B组(胸腺肽α1+布地奈德混悬液)。对比2组患者的住院时间,治疗前和拔管即刻体液免疫功能、细胞免疫功能、机械通气期间肺部感染发生率及药物不良反应发生率。结果:B组患者的住院时间短于A组(P<0.05);治疗前2组患者各项免疫功能指标比较,差异无统计学意义(P均>0.05)。与治疗前比较,拔管即刻2组患者IgG、IgA、IgM、补体C3、补体C4、自然杀伤细胞(NK)比例、CD3+比例、CD4+比例、CD4+/CD8+值升高,且B组更高(P均<0.05),CD8+比例降低,且B组更低(P<0.05);机械通气期间2组患者肺部感染发生率分别为1.92%和17.39%,B组低于A组(P<0.05);2组患者药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对于老年气管切开患者应用布地奈德混悬液联合胸腺肽α1,能够缩短治疗时间,提高患者免疫功能,降低肺部感染发生率。
    英文摘要:
          Abstract Objective: To investigate the preventive effect of budesonide suspension combined with thymosin α1 on pulmonary infection in elderly patients with tracheotomy. Methods: The data of 98 elderly tracheotomy patients admitted to the hospital were retrospectively analyzed. The patients were divided into group A (thymosin α1) and group B (thymosin α1 + budesonide suspension) according to different treatment protocols. The length of hospital stay, the humoral immune function and cellular immune function indexes before and immediately after extubation, the incidence of lung infection during mechanical ventilation, and the incidence of adverse drug reactions during mechanical ventilation were compared between the two groups. Results: The hospital stay in the group B was shorter than that in group A (P< 0.05). There were no significant differences in the immune function indexes between the two groups before treatment (P> 0.05). The IgG, IgA, IgM, complement C3, complement C4, NK cell ratio, CD3+ ratio, CD4+ ratio, CD4+/CD8+ values immediately after extubation were increased in both groups (P< 0.05), and those in the group B were higher than those in group A (P< 0.05). CD8+ ratio was reduced in both groups (P <0.05), and that in the group B was lower than in group A (P <0.05). The incidence of pulmonary infection during mechanical ventilation in the two groups was 1.92% and 17.39%, respectively, and that in group B was lower than that in group A (P< 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P< 0.05). Conclusion: For elderly patients with tracheotomy, budesonide suspension combined with thymosin α1 can reduce treatment time, improve the immune function of patients and decrease the incidence of pulmonary infection.