急性胰腺炎早期抗炎治疗研究进展
Advances in early anti-inflammatory treatment of acute pancreatitis

范正阳.急性胰腺炎早期抗炎治疗研究进展[J].内科急危重症杂志,2022,28(1):11-14

DOI：10.11768/nkjwzzzz20220102

英文关键词:

基金项目:国家自然科学基金面上项目(No:32170788)

作者	单位	E-mail
范正阳	北京协和医院消化内科疑难重症及罕见病国家重点实验室	wudong@pumch.cn

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中文摘要:

急性胰腺炎是多种致病因素导致的一种胰腺炎症性疾病，表现为急性腹痛、血清胰酶升高。重症患者可出现胰腺坏死、器官衰竭甚至死亡。炎性细胞因子在急性胰腺炎中起关键作用，炎症级联反应是驱动病情进展的主要因素。急性胰腺炎的早期治疗以对症支持为主。近年来，基础和临床研究提示早期应用非甾体类抗炎药（NSAIDs）治疗急性胰腺炎有效。本文对NSAIDs治疗急性胰腺炎的研究进行综述。

英文摘要:

Acute pancreatitis is an inflammatory disease of the pancreas caused by multiple pathogenic factors, manifested by acute abdominal pain and elevated serum pancreatic enzymes. In severe cases, pancreatic necrosis, organ failure and even death may occur. Inflammatory cytokines play a key role in acute pancreatitis, and the inflammatory cascade response is the main factor driving the progression of the disease. The early treatment of acute pancreatitis is based on symptomatic support. In recent years, basic and clinical studies have suggested that early application of non-steroidal anti-inflammatory drugs (NSAIDs) is effective in the treatment of acute pancreatitis. This article reviews the studies of NSAIDs in the treatment of acute pancreatitis.