马玲瑛.大动脉炎的诊治进展[J].内科急危重症杂志,2022,28(2):95-98
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| DOI：10.11768/nkjwzzzz20220202 |
| 中文关键词: 大动脉炎 诊断 治疗 进展 |
| 英文关键词: |
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| 中文摘要: |
| 大动脉炎（TAK)是一种主要累及主动脉及其分支的原发性大血管炎，多见于40岁以下的年轻女性。病理表现为多核巨细胞浸润、肉芽肿形成的全层性主动脉炎。大多数患者病情隐匿，也有少数急性起病，慢性持续性血管壁炎症和损害可导致管腔狭窄或闭塞，部分为动脉瘤形成。活动期积极治疗以缓解症状，阻止血管壁炎症进展，保护脏器的功能，改善预后。 |
| 英文摘要: |
| Takayasu arteritis (TAK) is a primary large vessel vasculitis that develops mainly in young women under the age of 40. The condition primarily involves the aorta and its branches.The pathological manifestations of TAK are full-thickness aortitis with multinucleated giant cell infiltration and granuloma formation. The disease is insidious in most patients. Chronic persistent inflammation and damage of the vessel wall can lead to lumen stenosis or occlusion, some of which are aneurysm formation. Active treatment in TAK can relieve symptoms, prevent the progression of vascular wall inflammation, protect organ function and improve prognosis. |
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