血清缺氧诱导因子-1α、微小RNA-210水平对急性脑梗死患者早期神经功能改善有预测价值

王雪琳.血清缺氧诱导因子-1α、微小RNA-210水平对急性脑梗死患者早期神经功能改善有预测价值[J].内科急危重症杂志,2022,28(4):312-314

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DOI：10.11768/nkjwzzzz20220413

中文关键词: HIF-1α mir-210 急性脑梗死神经功能早期改善关系

英文关键词:

基金项目:武汉市医学科研项目（No:WX20D76）

作者	单位	E-mail
王雪琳	武汉科技大学附属武昌医院	704970468@qq.com

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中文摘要:

目的：观察急性脑梗死患者血清缺氧诱导因子-1α(HIF-1α)、微小RNA-210(mir-210)水平与早期神经功能改善的关系。方法：根据早期(24 h) 卒中神经功能量表（NIHSS）评分改善情况，将收治的105例急性脑梗死病例分为早期NIHSS评分改善>75%组(38例)、改善50%~75%组(46例)、改善<50%组(21例)。入选病例均于治疗前检测血清HIF-1α、mir-210水平，并于治疗前、治疗后24 h进行NIHSS评分。采用Pearson秩相关法分析血清HIF-1α、mir-210与NIHSS评分之间的相关性。结果：改善>75%组、改善50%~75%组、改善<50%组血清HIF-1α、mir-210表达水平依次升高(P均<0.05)。经Pearson秩相关性分析，血清HIF-1α水平及血清mir-210水平与NIHSS改善值呈负相关(OR= -0.957、-0.920，P均<0.01)。以血清HIF-1α、mir-210鉴别NIHSS改善分级的曲线位于参考线之上，敏感度、特异性均高于80%。结论：急性脑梗死患者早期存在血清HIF-1α、mir-210异常高表达，且其表达水平在早期神经功能改善预测中具有一定的临床价值。

英文摘要:

Objective: To explore the relationship between the serum level of hypoxia-inducible factor (HIF-1α), the microRNA-210 (Mic-210) and the early neurological function improvement in patients with acute cerebral infarction (ACI). Methods: According to the improvement of early (24h) stroke neurological function scale (NIHSS) score, 105 cases of ACI were divided into three groups: above 75% group (38 cases), 50% to 75% group (46 cases), and below 50% group (21 cases). The patients were tested for the serum HIF-1α, the Mic-210, and the NIHSS score of 24h both before and after treatment. The correlation between the serum HIF-1α and the NIHSS score was analyzed by the Pearson rank correlation method. Results: The serum level of HIF-1α and Mic-210 was elevated orderly in above 75 group, 50%-75% group and below 50% group. The serum levels of HIF-1α and Mic-210 were negatively correlated with the NIHSS score improvement (OR=-0.957, P<0.01; OR=-0.920, P<0.01). The curve of the serum HIF-1α, and Mic-210 in identifying the NIHSS improvement grade was located above the reference line, with the sensitivity and specificity both above 80%. Conclusion: The HIF-1α and Mic-210 are highly expressed in early ACI patients, and have some clinical predictive value in the early neurofunction improvement.