曾宗鼎.血浆miR-142a-5p水平预测急性肺损伤患者28天病死率的价值[J].内科急危重症杂志,2022,28(4):315-317
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| DOI：10.11768/nkjwzzzz20220414 |
| 中文关键词: 急性肺损伤 miR-142a-5p 预后评估 |
| 英文关键词: |
| 基金项目:海南省医药卫生科研基金项目(No：18A200005) |
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| 中文摘要: |
| 目的：探讨急性冠脉综合征（ACS）患者经皮冠状动脉介入治疗（PCI）后血液中单核细胞计数/高密度脂蛋白的比值（MHR）与主要不良心血管事件（MACE）的相关性。方法： 收集接受PCI的120例ACS患者的临床资料，分为院内出现MACE组和正常出院组（ND组），比较2组患者的MHR水平，采用Logistic回归分析各因素与ACS患者发生MACI的关系，采用Spearman分析法分析MHR与Gensini评分相关性；采用受试者工作特征曲线(ROC)分析MHR对MACE的预测价值。结果： MACE组患者年龄、高血压、Gensini评分、MHR、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB） 、脂蛋白（LP）、尿酸（UA）水平明显高于ND组（P均＜0.05），MHR、LP(a)为ACS患者的独立危险因素（P均＜0.05），MHR与Gensini评分呈正相关(r=0.832，P＜0. 05)， MHR的预测临界值为9.45，MHR≥9.45的患者1年内再次住院率明显高于MHR＜9.45的患者。结论： 血清MHR与ACS患者PCI术后冠状动脉病变的严重程度呈正相关，可作为ACS患者PCI术后发生院内MACE的独立预测因素。 |
| 英文摘要: |
| Objective: To investigate the correlation between blood monocyte count/high-density lipoprotein ratio (MHR) and major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) . Methods: The clinical data of 120 patients with ACS who underwent PCI were collected. The patients were divided into the MACEs group and the normal discharge group (ND group). The MHR levels in the two groups were compared. Logistic regression was used to analyze the relationship between each factor and ACS patients. Spearman analysis was used to analyze the correlation between MHR and Gensini score. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of MHR for MACEs. Results: The age, hypertension, Gensini score, MHR, ApoA1, ApoB, LP(a), and uric acid (UA) levels in the MACEs group were significantly higher than those in the ND group, and the differences were statistically significant (P<0.05). MHR and LP(a) were independent risk factors for ACS patients, and the differences were statistically significant (P<0.05). The level of MHR was positively correlated with the Gensini score (r=0.832, P<0.05), and the predictive critical value of MHR was 9.45. The probability of re-hospitalization within 1 year was significantly higher in patients with MHR ≥ 9.45 than in patients with MHR< 9.45. Conclusion: Serum MHR is positively correlated with the severity of coronary artery disease after PCI in patients with ACS, and can be used as an independent predictor of MACEs in patients with ACS after PCI. |
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