朋毛措.骨化性气管支气管病4例及文献复习[J].内科急危重症杂志,2022,28(5):374-377
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| DOI：10.11768/nkjwzzzz20220505 |
| 中文关键词: 骨化性气管支气管病 临床特征 气管骨化 骨性结节 |
| 英文关键词: |
| 基金项目:国家自然科学基金面上项目（No.82170049,81973986）；湖北省公共卫生领军人才（2022SCZ047) |
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| 中文摘要: |
| 目的:总结骨化性气管支气管病(TO)的临床特点，减少临床误诊率及漏诊率。方法:收集我院诊治的4例TO患者的临床资料，并检索国内数据库，总结116例TO患者的临床特点。结果:116例TO中男性65例，女性51例。临床表现无特异性，以组合性呼吸道症状多见。支气管镜检查可见气管及支气管前壁及侧壁黏膜下多发质硬结节，突向管腔，后壁不易受累。组织病理活检可见黏膜下出现软骨或成熟骨组织。治疗上对症处理，出现严重管腔狭窄可采用内镜介入或外科手术。结论：TO是一种预后较好的良性疾病， 支气管镜及组织病理活检有特征性改变,可以确诊。 |
| 英文摘要: |
| Objectives: To summarize the clinical characteristics of tracheobronchopathia osteochondroplastica (TO), and to reduce the clinical misdiagnosis and underdiagnosis rates. Methods: A total of 4 cases of TO admitted to our hospital were selected, and the domestic literature was searched to summarize the clinical characteristics of 116 patients. Results: Among the 116 cases of TO, 65 cases were male and 51 cases were female. The clinical manifestations were non-specific, with combined respiratory symptoms prevalent. Bronchoscopy revealed multiple submucosal hard nodules on the anterior and lateral walls of the trachea and bronchi, protruding into the lumen, and the posterior wall was not easily involved. Histopathological biopsy revealed submucosal cartilage or mature bone tissue. Treatment is mainly symptomatic, with endoscopic intervention or surgical excision of nodules with severe luminal narrowing. Conclusion: TO is a benign disease with a good prognosis. Bronchoscopy and histopathological biopsy have characteristic changes, and a definite diagnosis can be made. |
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