高尿酸联合BNP、CRP、HCY可预测急性心肌梗死患者主要不良心血管事件

陈东.高尿酸联合BNP、CRP、HCY可预测急性心肌梗死患者主要不良心血管事件[J].内科急危重症杂志,2022,28(6):504-507

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DOI：10.11768/nkjwzzzz20220616

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基金项目:2018年安徽省心血管研究所第二批科研项目（No:KF2018005）

作者	单位	E-mail
陈东	安徽医科大学临床学院合肥市第三人民医院	chengdong0038@sina.com

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中文摘要:

摘要目的：探讨急性心肌梗死患者高血尿酸（HSUA）与B型钠尿肽（BNP）、C反应蛋白（CRP）、同型半胱氨酸（HCY）及主要不良心血管事件（MACE）的相关性。方法：选取急性心肌梗死患者123例，根据血尿酸（SUA）水平分为实验组（＞420μmoI/L）和对照组（≤420μmoI/L ）。分析2组临床基本资料特征及HSUA与急性心肌梗死后MACE的相关性。结果：与对照组比较，实验组血SUA、BNP、CRP、HCY水平更高（P＜0.05或 P＜0.01）。Spearman相关性分析显示HSUA与BNP、CRP、HCY呈正相关（r=0.256、0.237、0.374，P均＜0.01）。Kaplan Meier生存分析示1年随访期实验组累积MACE发生率高于对照组（86.5％ vs 66.3％，P＜0.05）。多因素Cox分析结果示，HSUA和BNP是影响MACE发生的独立预测因子（HR=33.878、13.361，95%CI：1.077~1065.761、1.319~135.330，P均＜0.05）。结论：急性心肌梗死患者HSUA与BNP、CRP、HCY有关，是急性心肌梗死后MACE发生的一个独立预测因子。

英文摘要:

Abstract Objective: To investigate the correlation of hyperuricemia with B-type natriuretic peptide (BNP), C-reactive protein (CRP), homocysteine (HCY) and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction. Methods: Totally, 123 cases of acute myocardial infarction were seleted, and divided into experimental group (> 420 μmoI/L) and control group (≤420μmoI/L) according to the level of serum uric acid (SUA). The clinical characteristics of the two groups and the correlation between HSUA and MACE were analyzed after acute myocardial infarction. Results: Compared with the control group, the levels of SUA, BNP, CRP and HCY were significant increased in the experimental group (P< 0.05 or P< 0.01). Spearman correlation analysis showed that high HSUA was correlated with BNP, CRP and HCY positively (r= 0.256, 0.237, 0.374, all P< 0.01). Kaplan-Meier survival analysis showed that the cumulative incidence of MACE in the experimental group was higher than in the control group (86.5% vs 66.3%, P< 0.05). Multivariate Cox analysis showed that HSUA and BNP were independent predictors of MACE (HR=33.878, 13.361; 95%CI: 1.077-1065.761, 1.319-135.330; P< 0.05). Conclusion: HSUA is associated with BNP, CRP and HCY in patients with acute myocardial infarction, and it is an independent predictor of MACE in patients with acute myocardial infarction.