血清甘油三酯-血糖指数、糖化血清蛋白及视黄醇结合蛋白4水平与冠状动脉病变程度相关
Relationship between serum levels of TGG index, glycosylated serum protein and retinol binding protein 4 and the degree of coronary artery disease

谭三阳.血清甘油三酯-血糖指数、糖化血清蛋白及视黄醇结合蛋白4水平与冠状动脉病变程度相关[J].内科急危重症杂志,2022,28(1):46-49

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DOI：10.11768/nkjwzzzz20220110

中文关键词: 甘油三酯-血糖指数糖化血清蛋白视黄醇结合蛋白4 冠状动脉粥样硬化

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作者	单位	E-mail
谭三阳	海南省海口市妇幼保健院检验科	huanghai1975@163.com

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中文摘要:

目的：探讨血清甘油三酯-血糖（TG-G）指数、糖化血清蛋白（GSP）和视黄醇结合蛋白4（RBP4）水平与冠状动脉粥样硬化病变程度的相关性。方法：选择2019年1月-2020年1月海南省海口市妇幼保健院接受冠状动脉造影患者共146例，根据术中目视直径法判断冠脉无狭窄（狭窄直径＜50%）患者31例，轻度狭窄（50%~75%,不包括75%）患者38例，中度狭窄（75%~90%）患者42例，重度狭窄（＞90%）患者35例。比较4组患者血清TG-G指数、GSP和RBP4水平，采用Pearson检验分析血清TG-G指数、GSP和RBP4水平与冠脉病变 Gensini积分的相关性，采用受试者工作特征（ROC）曲线分析血清TG-G指数、GSP和RBP4水平预测冠心病的准确性。结果：随着冠脉狭窄程度的升高，血清TG-G指数、GSP和RBP4水平也逐渐增加（P均＜0.05）。血清TG-G指数、GSP和RBP4水平与冠脉病变 Gensini积分呈正相关性（r=0.803、0.823、0.915，P=0.027、0.016、0.004）。血清TG-G指数、GSP和RBP4水平预测冠心病的准确性分别为0.824、0.833和0.854。结论：冠心病患者血清TG-G指数、GSP和RBP4水平升高，与冠心病严重程度相关，可能成为预测冠心病的无创敏感指标。

英文摘要:

Objective: To explore the relationship between serum levels of TGG index, glycosylated serum protein(GSP) and retinol binding protein 4(RBP4) and the degree of coronary atherosclerosis. Methods: From January 2019 to January 2020, 146 patients were enrolled in our hospital for coronary angiography, including 31 patients without stenosis (stenosis diameter<50%), 38 patients with mild stenosis (50%-<75%), 42 patients with moderate stenosis (75%-90%), and 35 patients with severe stenosis (> 90%). The serum TGG index, GSP and RBP4 levels were compared among the groups. The Pearson test was used to analyze the correlation between serum TGG index, GSP and RBP4 levels and the Gensini score of coronary artery disease. Finally, the receiver operating characteristic (ROC) curve was used to analyze the accuracy of serum TGG index, GSP and RBP4 levels predicting coronary heart disease. Results: With the increase of degree of coronary stenosis, serum TGG index, GSP and RBP4 levels increased gradually (P<0.05). Serum TGG index, GSP and RBP4 levels were positively correlated with Gensini score (r=0.803, 0.823, 0.915, P values were 0.027, 0.016, 0.004, respectively). The accuracy of serum TGG index, GSP and RBP4 levels for predicting coronary heart disease was 0.824, 0.833 and 0.854, respectively. Conclusion: The levels of serum TGG index, GSP and RBP4 were increased in patients with coronary heart disease, which has a good correlation with the severity of coronary heart disease, and may become important sensitive indicators for non-invasive prediction of coronary heart disease.