汪亦君.SNAT1、SNAT2和SNAT4在胃肠道肿瘤中的研究进展[J].内科急危重症杂志,2023,29(1):11-13
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| DOI：10.11768/nkjwzzzz20230103 |
| 中文关键词: 胃肠道肿瘤 氨基酸转运蛋白 溶质载体 钠离子依赖的中性氨基酸转运蛋白 |
| 英文关键词: |
| 基金项目:国家自然科学基金面上项目（No:82273310; No:81972237），湖北省自然科学基金创新群体项目（No:2022CFA016） |
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| 中文摘要: |
| 摘要 近年来，胃肠道肿瘤在全球的发病率和死亡率高居不下，了解其发病机制对肿瘤治疗至关重要。肿瘤细胞广泛地重编程其氨基酸代谢途径以支持其增加的生物合成和能量需求。氨基酸转运蛋白控制氨基酸在细胞脂质膜上的运输，对维持体内稳态和肿瘤代谢需求至关重要。不同的细胞状态需要与其功能需求相兼容的氨基酸转运体的表达和功能 。SNAT1、SNAT2和SNAT4都属于SLC38家族系统A氨基酸转运蛋白，可以转运丙氨酸、丝氨酸、谷氨酰胺、半胱氨酸、天冬酰胺等氨基酸。SNAT1、SNAT2和SNAT4在许多代谢疾病和肿瘤疾病中发挥着不可忽视的作用。本文对SNAT1、SNAT2和SNAT4在胃肠道肿瘤中的研究进展进行综述。 |
| 英文摘要: |
| Abstract The morbidity and mortality of gastrointestinal cancers remain high worldwide in recent years. Therefore, understanding the pathogenesis of these diseases is crucial for cancer treatment. Cancer cells reprogram their amino acid metabolism pathways to meet their increased biosynthetic and bioenergetic demands. Amino acid transporters control amino acid transport on the cellular lipid membranes and are essential for maintaining body homeostasis and meeting tumor metabolic demands. Distinct cellular states require amino acid transporter expression and function compatible with their functional requirements. SNAT1, SNAT2 and SNAT4 belong to the system A amino acid transporter of the SLC38 family and can transport amino acids such as alanine, serine, glutamine, cysteine, and asparagine. SNAT1，SNAT2and SNAT4 play significant roles in many metabolic and neoplastic diseases. This review summarizes the research progress of SNAT1, SNAT2, and SNAT4 in gastrointestinal cancers. |
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