李新强.血清纤溶酶原激活物抑制剂-1、单核细胞趋化蛋白-1水平升高有助于诊断重症急性胰腺炎并发胰腺感染[J].内科急危重症杂志,2023,29(1):34-36
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| DOI：10.11768/nkjwzzzz20230109 |
| 中文关键词: 重症急性胰腺炎 纤溶酶原激活物抑制剂-1 单核细胞趋化蛋白-1 胰腺感染 诊断价值 |
| 英文关键词: |
| 基金项目:陕西省自然科学基础研究计划项目（No:2020JM-654） |
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| 中文摘要: |
| 摘要 目的：探究重症急性胰腺炎（SAP）患者血清纤溶酶原激活物抑制剂-1（PAI-1）、单核细胞趋化蛋白1（MCP-1）表达水平对SAP并发胰腺感染的诊断价值。方法：选取132例SAP患者，根据发病2周后是否并发胰腺感染分为感染组（40例）和非感染组（92例）。采用酶联免疫吸附法（ELISA）检测所有患者入院次日血清中PAI-1、MCP-1水平。采用受试者工作特征曲线（ROC）分析血清PAI-1、MCP-1水平对SAP并发胰腺感染的诊断价值。采用Logistic回归分析影响SAP并发胰腺感染的危险因素。结果：与非感染组比较，感染组住院天数较长，死亡率、手术率、血清PAI-1水平及MCP-1水平较高（P均＜0.05）；ROC显示，血清PAI-1、MCP-1水平单独诊断SAP并发胰腺感染的曲线下面积（AUC）为0.796、0.760，二者联合诊断SAP并发胰腺感染的AUC为0.845（95%CI:0.773~0.917），敏感度、特异性分别为85.00%、76.10%。Logistic分析显示，PAI-1、MCP-1是重症胰腺炎并发胰腺感染的危险因素（P均＜0.05）。结论：SAP并发胰腺感染患者血清PAI-1、MCP-1水平上升，PAI-1联合MCP-1有助于SAP并发胰腺感染早期诊断。 |
| 英文摘要: |
| Abstract Objective: To explore the diagnostic value of serum plasminogen activator inhibitor-1 (PAI-1) and monocyte chemotactic protein-1 (MCP-1) expression levels in patients with severe acute pancreatitis (SAP) complicated with pancreatic infection. Methods: A total of 132 patients with SAP were divided into infected group (40 cases) and uninfected group (92 cases) according to whether they were complicated with pancreatic infection within 2 weeks. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of PAI-1 and MCP-1 in serum on the day after admission. The ROC method was used to analyze the diagnostic value of serum PAI-1 and MCP-1 levels in SAP complicated with pancreatic infection. Logistic regression was used to analyze the risk factors affecting SAP complicated with pancreatic infection. Results: As compared with the uninfected group, the hospital stay (days), mortality, operation rate, the serum PAI-1 and MCP-1 levels in the infected group were higher (P<0.05); ROC results showed that the area under the curve (AUC) of serum PAI-1 and MCP-1 levels in the diagnosis of SAP complicated with pancreatic infection was 0.796 and 0.760 respectively, the AUC of the two combined diagnosis of SAP complicated with pancreatic infection was 0.845 (95%CI: 0.773-0.917), and the sensitivity and specificity were 85.00% and 76.10%, respectively. Logistic analysis showed that PAI-1 and MCP-1 were risk factors for severe pancreatitis complicated with pancreatic infection (P<0.05). Conclusion: The levels of serum PAI-1 and MCP-1 in patients with SAP complicated with pancreatic infection increase. The combination of PAI-1 and MCP-1 is helpful for the early diagnosis of SAP complicated with pancreatic infection. |
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