周泽伟.血清血管紧张素转化酶2、前白蛋白及血小板活化因子水平能够预测重症急性胰腺炎预后[J].内科急危重症杂志,2023,29(1):49-50
扫码阅读全文
|
| DOI：10.11768/nkjwzzzz20230113 |
| 中文关键词: 血管紧张素转化酶2 前白蛋白 血小板活化因子 重症急性胰腺炎 预测价值 |
| 英文关键词: |
| 基金项目:重庆市科委地方病重大专项基金(No：AB5055;No：AB5008;No：AB5054) |
|
| 摘要点击次数: 1230 |
| 全文下载次数: 1473 |
| 中文摘要: |
| 摘要 目的: 探讨血清血管紧张素转化酶2（ACE2）、前白蛋白（PAB）及血小板活化因子（PAF）水平对重症急性胰腺炎（SAP）患者预后的评估意义。方法：收集69例重症急性胰腺炎患者为研究组，选择同期体检健康者70例作为对照组，分析2组血清ACE2、PAB、PAF水平、急性生理和慢性健康状况评估系统Ⅱ（APACHEⅡ）评分的变化。采用受试者工作特征曲线分析血清ACE2、PAB及PAF对预后的预测价值。结果: 研究组患者血清ACE2、PAB水平在第1、3、7d时显著低于对照组（P均<0.05），PAF水平、APACHEⅡ评分在第1、3、7d时显著高于对照组（P均＜0.05）；死亡患者血清ACE2、PAB水平显著低于存活患者，PAF水平、APACHEⅡ评分显著高于存活患者（P均＜0.05）；Pearson相关分析，血清ACE2、PAB与APACHEⅡ之间呈负相关（P均<0.05），血清PAF与APACHEⅡ之间呈正相关（P＜0.05）；ACE2联合PAB检测曲线下面积（AUC）为0.988，95%CI为0.975~0.997，与AVE2、PAB单独检测比较，AUC更大（Z=3.12、2.025、1.964，P均＜0.05），且联合检测特异性、灵敏度均更高。结论:血清ACE2、PAB及PAF的表达与APACHEⅡ评分密切相关，对SAP预后具有较高的预测价值。 |
| 英文摘要: |
| Abstract Objective: To explore the prognostic value of spontaneous intracerebral cerebral hemorrhage (SICH) score combined with coagulation parameters in patients with SICH. Methods: The clinical data of 106 patients with SICH were retrospectively analyzed. According to the survival within 30 d after admission, the patients were divided into death group (31 cases) and survival group (75 cases). The two groups were compared in terms of Hemphill intracerebral hemorrhage score, coagulation parameters [D-dimer (D-D), antithrombin (AT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT)] at admission. The Pearson correlation analysis was used to analyze the correlation between SICH score and coagulation parameters in SICH patients, and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value of SICH score and coagulation parameters on the short-term prognosis of SICH patients. Results: There was no significant difference between the two groups in terms of gender, age, volume of hematoma on admission, incidence of ventricular rupture, admission blood glucose and hypertension, history of diabetes, smoking history, drinking history, and fever on admission (P> 0.05). The blood pressure in the death group was higher than that in the survival group at admission, and the volume of hematoma at 72h after admission was larger than that in the survival group (P< 0.05). The SICH score, D-D and FIB in the death group were higher than those in the survival group, and AT was lower than that in the survival group (P< 0.05). The Pearson correlation analysis showed that the SICH score of SICH patients was significantly positively correlated with blood D-D and FIB (r=0.366, 0.364, P< 0.05), and negatively correlated with AT (r=-0.342, P <0.05). The ROC curve showed that SICH score, D-D, FIB and AT had high predictive value for the recent adverse prognosis of patients with SICH (AUC=0.841, 0.886, 0.746, 0.867, P< 0.05), and their cut-off values were 2.50 points, 0.91mg/L, 253.99mg/L and 4.60g/L respectively, and the AUC value of four indicators was 0.991, which was the highest predictive value. Conclusion: SICH score combined with D-D, FIB and AT can predict the short-term prognosis of SICH patients. |
|
|
|
|
