苏莹.2型糖尿病心外膜脂肪:冠心病新的防治靶点[J].内科急危重症杂志,2023,29(2):119-122
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| DOI：10.11768/nkjwzzzz20230206 |
| 中文关键词: 2型糖尿病 冠心病 心外膜脂肪 炎症反应 |
| 英文关键词: |
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| 中文摘要: |
| 异位脂肪的过量堆积是2型糖尿病（T2DM)发生冠心病的高危因素。心外膜脂肪（EAT）是紧邻心肌和冠状动脉的一种异位脂肪。在T2DM患者体内，EAT的容积和功能学发生变化，通过分泌脂肪因子、炎症因子和游离脂肪酸等，促进冠状动脉的内皮及平滑肌发生胰岛素抵抗、损伤和炎症反应，并引起心肌的损伤，进而加快冠心病的发生及发展，增加心肌缺血和斑块破裂等冠心病事件的发生。现有证据表明EAT可能是T2DM合并冠心病的治疗靶点，本文将对这一领域的研究进展进行总结及展望。 |
| 英文摘要: |
| Excessive accumulation of ectopic adipose tissue is a high-risk factor for coronary heart disease in type 2 diabetes mellitus (T2DM). Epicardial adipose tissue (EAT) is a type of ectopic fat adjacent to the myocardium and coronary arteries. In T2DM settings, the volume and function of EAT have undergone dramastic alteration. By secreting adipokines, inflammatory factors and free fatty acids, EAT promotes local insulin resistance, damage and inflammation in cellular components of coronary arteries. Moreover, factors from EAT directly cause damage to myocardium. Thereby, EAT in T2DM increases the occurrence of coronary heart disease and susceptibility of myocardium to ischemic events. Existing evidence suggests that EAT may be potential therapeutic target for T2DM combined with coronary heart disease. This review intends to probe into the current proceedings in this field and future research highlights. |
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