梁文文.卒中后抑郁与脑源性神经营养因子的研究进展[J].内科急危重症杂志,2023,29(3):185-188
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| DOI：10.11768/nkjwzzzz20230303 |
| 中文关键词: 卒中 抑郁 卒中后抑郁 脑源性神经营养因子 |
| 英文关键词: |
| 基金项目:国家自然科学基金（No:82171465；No:82001272） |
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| 中文摘要: |
| 摘要 卒中后抑郁（PSD）是卒中后最常见且可治疗的精神并发症，可显著影响卒中的预后，给患者、家庭和社会带来沉重的负担。脑源性神经营养因子(BDNF）是神经营养家族中的重要成员，在神经发生和突触可塑性起重要作用。BDNF在卒中和抑郁的发生、发展中的作用已得到广泛的研究证实。近年来，越来越多研究开始关注BDNF在PSD发生过程中的作用，本文综述了BDNF在PSD中的作用机制和治疗现状，以指导个体化和精确化的PSD诊疗。 |
| 英文摘要: |
| Abstract Post-stroke depression (PSD) is the most common and treatable mental complication after stroke, which can significantly affect the prognosis of stroke and bring heavy burden to patients, their families and society. Brain-derived neurotrophic factor (BDNF) is an important component of the neurotrophic family and plays an important role in neurogenesis and synaptic plasticity. The role of BDNF in the development and progression of stroke and depression has been investigated in depth respectively. In recent years, more and more studies have focused on the role of BDNF in the development of PSD. This article reviews the mechanism of BDNF in PSD and the current status of treatment to guide the individualized and precise diagnosis and treatment of PSD. |
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