张云.血清ICAM-1、MMP-9和Cys-C水平可评估急性脑出血患者的病情和预后[J].内科急危重症杂志,2023,29(3):199-202
扫码阅读全文
|
| DOI：10.11768/nkjwzzzz20230306 |
| 中文关键词: 急性脑出血 细胞间黏附分子-1 基质金属蛋白酶-9 胱抑素-C 严重程度 预后评估 |
| 英文关键词: |
| 基金项目:南通市2018年度市级科技计划项目（No：MSZ18060） |
|
| 摘要点击次数: 629 |
| 全文下载次数: 908 |
| 中文摘要: |
| 目的：探讨急性脑出血（ACH）患者血清细胞间黏附分子-1（ICAM-1）、胱抑素-C（Cys-C）、基质金属蛋白酶-9（MMP-9）水平对判断病情和预后的意义。方法：将收治的105例ACH患者列入观察组，按照格拉斯哥昏迷评分（GCS）分成轻、中、重度3个亚组；选择同期98例健康体检者列入对照组。检测并比较2组间血清ICAM-1、MMP-9和Cys-C等水平差异。 结果：观察组入院时、治疗1周和2周后的ICAM-1、MMP-9和Cys-C水平高于对照组（P均＜0.05）；观察组入院时和治疗1周后的ICAM-1水平、MMP-9和Cys-C水平高于治疗2周后（P均＜0.05），且观察组入院时MMP-9和Cys-C水平最高（P均＜0.05）。在观察组中，重度组的血清ICAM-1、MMP-9和Cys-C水平高于中度组和轻度组，且中度组又高于轻度组（P均＜0.05）；重度组的心血管不良事件发生率、并发症发生率和死亡率高于中度组和轻度组，且中度组又高于轻度组（P均＜0.05）。 结论：ACH患者血清ICAM-1、MMP-9和Cys-C水平与病情严重程度显著相关，可作为ACH患者的病情进展和疾病预后评估的可靠指标。 |
| 英文摘要: |
| Abstract Objective: To investigate the significance of serum intercellular adhesion analysis-1 (ICAM-1), cystatin C (Cys-C) and matrix metalloproteinase-9 (MMP-9) levels in patients with acute intracerebral hemorrhage (ACH). Methods: A total of 105 ACH patients were included in the observation group, and were divided into mild, moderate and severe subgroups according to the Glasgow coma score (GCS). A total of 98 healthy subjects were included in the control group. Serum levels of ICAM-1, MMP-9 and Cys-C were detected and compared between the two groups. Results: The levels of ICAM-1, MMP-9 and CYS-C in the observation group at admission, 1 week and 2 weeks after treatment were higher than those in the control group (P< 0.05). In the observation group, the ICAM-1 level at admission and 1 week after treatment was higher than that after 2 weeks of treatment (P< 0.05), and there was no significant difference between the two groups at admission and 1 week after treatment (P> 0.05). The levels of MMP-9 and Cys-C at admission and 1 week after treatment were higher than those after 2 weeks of treatment, and the observation group had the highest levels of MMP-9 and Cys-C at admission (all P< 0.05). In the observation group, the serum levels of ICAM-1, MMP-9 and Cys-C in the severe disease group were higher than those in the moderate and mild groups, and those in the moderate group was higher than in the mild group (all P< 0.05). The incidence of adverse cardiovascular events, complications and mortality in the severe group were higher than those in the moderate and mild groups, and that in the moderate group was higher than that in the mild group (all P< 0.05). Conclusion: Serum levels of ICAM-1, MMP-9 and Cys-C in ACH patients were significantly correlated with the severity of the disease, which could be used as a reliable indicator for the evaluation of the disease progression and prognosis in ACH patients. |
|
|
|
|
