沈克锋.ctDNA在B细胞淋巴瘤中的研究进展[J].内科急危重症杂志,2023,29(5):370-376
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| DOI：10.11768/nkjwzzzz20230504 |
| 中文关键词: 循环肿瘤DNA 液态活检 二代测序 B细胞淋巴瘤 微小残留病灶 |
| 英文关键词: |
| 基金项目:国家自然科学基金（No:82270203） |
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| 中文摘要: |
| 摘要 循环肿瘤DNA（ctDNA）是肿瘤患者体液循环中一种广泛存在的游离DNA片段，相较于肿瘤实体病灶，ctDNA具有取材方便、安全无创、信息全面等优势。ctDNA检测可应用于B细胞淋巴瘤的治疗前、治疗中和治疗后等各个阶段，在肿瘤辅助诊断、预后分层、靶向治疗、疗效评估、微小残留病灶（MRD）监测及预测复发等方面具有重要指导意义。本文主要就ctDNA在B细胞淋巴瘤中的相关检测手段、应用进展和前景展望等作一概述。 |
| 英文摘要: |
| Abstract Circulating tumor DNA (ctDNA) refers to the cell-free DNA fragments that are widely distributed in the body fluids of tumor patients. Compared with solid tumor lesions, a competitive advantage of ctDNA is its easy accessibility, non-invasive, and comprehensive characteristics.ctDNA detection can be used at all episodes of B-cell lymphoma before, during, and after treatment, and it has important guiding significance in tumor auxiliary diagnosis, prognosis stratification, targeted therapy, efficacy evaluation, minimal residual disease (MRD) monitoring, and prediction of recurrence. In this review, we present an overview of current technical methods, application progress, and perspectives of ctDNA in B-cell lymphoma. |
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