阿替普酶联合抗血小板聚集治疗可影响急性缺血性脑卒中患者miR-150-5p及miR-199a表达水平

吴有林.阿替普酶联合抗血小板聚集治疗可影响急性缺血性脑卒中患者miR-150-5p及miR-199a表达水平[J].内科急危重症杂志,2023,29(6):480-483

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DOI：10.11768/nkjwzzzz20230609

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基金项目:四川省卫生和计划生育委员会科研课题（No:18PJ338)

作者	单位	E-mail
吴有林	崇州市人民医院	wwb9925h@163.com

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中文摘要:

摘要目的：观察阿替普酶联合抗血小板聚集治疗对急性缺血性脑卒中（AIS）患者miR-150-5p及miR-199a表达的影响。方法：选取150例AIS患者，随机分为对照组和观察组，每组75例。对照组予阿替普酶溶栓治疗，观察组在对照组的基础上联合抗血小板聚集治疗。比较2组美国国立卫生研究院卒中量表（NIHSS）、改良Rankin评分量表（mRS）、Barthel指数、miR-150-5p及miR-199a表达变化情况。比较2组患者早期神经功能恶化的发生率。结果：2组患者治疗14d后Barthel指数较治疗前升高，NIHSS、mRS评分较治疗前降低（P均＜0.05）。与对照组比较，观察组治疗14d后的临床总有效率、Barthel指数、血清miR-150-5p及miR-199a表达更高，而NIHSS、mRS评分更低（P均＜0.05）。2组患者早期（1周内）神经功能恶化总发生率比较，差异无统计学意义（P＞0.05）。结论：阿替普酶联合抗血小板聚集治疗AIS患者，可减轻神经功能损害，提高患者生活自理能力，还可上调miR-150-5p及miR-199a表达。

英文摘要:

Abstract Objective: To observe the effect of alteplase combined with antiplatelet therapy on the expression of micro ribonucleic acid-150-5p (miR-150-5p) and miR-199a in patients with acute ischemic stroke (AIS). Methods: A total of 150 patients with AIS were randomly divided into control group (n=75, receiving alteplase thrombolysis) and observation group (n=75, given alteplase thrombolysis combined with antiplatelet therapy). The National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Scale (mRS), Barthel index score, and the expression of miR-150-5p and miR-199a were compared between the two groups. The incidence of early neurological deterioration was compared between the two groups. Results: After 14 days of treatment in the two groups, the Barthel index score was higher than that before treatment, and the NIHSS and mRS scores were lower than those before treatment (all P<0.05). The total clinical effective rate, Barthel index score, and serum miR-150-5p and miR-199a expression levels in the observation group were higher after 14 days of treatment, while the NIHSS and mRS scores were lower after 14 days of treatment than the control group (all P<0.05). There was no significant difference in the total incidence of early neurological deterioration (within 1 week) between the two groups (P>0.05). Conclusion: Alteplase combined with antiplatelet therapy in the treatment of AIS patients can reduce the neurological damage, improve the self-care ability of patients, and upregulate the expression levels of miR-150-5p and miR-199a.