• 抗N-甲基-D-天冬氨酸受体脑炎精神行为异常的研究
  • 黄晓雪.抗N-甲基-D-天冬氨酸受体脑炎精神行为异常的研究[J].内科急危重症杂志,2024,30(3):206-211
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    DOI:10.11768/nkjwzzzz20240303
    中文关键词:  抗N-甲基-D-天冬氨酸受体脑炎  精神行为异常
    英文关键词:
    基金项目:国家自然科学基金资助项目(U1604181);河南省医学科技攻关计划联合共建项目(LHGJ20190078);河南省医学教育研究项目(wjlx2020531);河南省重点研发与推广专项(科技攻关)(212102310834);河南省自然科学基金(232300420043)
    作者单位
    黄晓雪 郑州大学第一附属医院 
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    中文摘要:
          摘要 抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是自身免疫性脑炎(AE)的最主要类型,精神行为异常是其常见、有时甚至是首发的临床症状,会造成患者首诊于精神科,极易导致漏诊、误诊和误治。因此,正确认识和识别抗NMDAR脑炎的精神行为异常有助于及早明确诊断、及时给予恰当的治疗、进而改善患者的预后。本文拟对抗NMDAR脑炎精神行为异常的发病机制、临床特点、辅助检查、治疗及预后等进行综述,为提高临床医生对抗NMDAR脑炎精神行为异常的认识和识别能力而提供帮助。
    英文摘要:
          Abstract Anti-N-methyl-D-aspartate receptor encephalitis, the most important type of autoimmune encephalitis, is prevalent and often initially characterized by mental and behavioral abnormalities. Patients may be admitted to a psychiatric department, leading to missed diagnosis, misdiagnosis, and mistreatment. Therefore, a proper understanding and identification of mental and behavioral abnormalities in anti-N-methyl-D-aspartate receptor encephalitis are crucial for early diagnosis, timely treatment, and improving the prognosis of patients. This article reviews the pathogenesis, clinical manifestations, auxiliary examination, treatment options, and prognosis of mental and behavioral abnormalities to support clinicians in enhancing their awareness and recognition of mental and behavioral abnormalities in anti-N-methyl-D-aspartate receptor encephalitis.