慢性阻塞性肺疾病前期研究进展
Abstract Chronic obstructive pulmonary disease (COPD) is a disease presenting incompletely reversible and persistent airflow obstruction, which needs a long time to be developed. If individuals who would develop COPD finally could be identified before the disease occurs, such as those with respiratory symptoms, structural or functional abnormalities but normal forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) at present (pre-COPD), interventions regarding risk factors and treatment in early stage could be implemented to slow down the disease progression. In this article we discussed studies relevant to potential indicators for pre-COPD and proposed the research direction of pre-COPD in the future.

樊静.慢性阻塞性肺疾病前期研究进展[J].内科急危重症杂志,2024,30(5):391-396

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DOI：10.11768/nkjwzzzz.20240502

英文关键词:

基金项目:北京市科技新星计划交叉合作课题（20220484157）；海淀转化专项基金（HDCXZHKC2021206）；院队列项目B类（BYSYDL2021013）；国家自然科学基金重大项目（82090014）

作者	单位	E-mail
樊静	北京大学第三医院	fangliwen@ncncd.chinacdc.cn

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中文摘要:

摘要慢性阻塞性肺疾病（简称慢阻肺）是不完全可逆的持续气流受限疾病。慢阻肺的发病是一个漫长的过程。如果能在慢阻肺尚未发病时提前发现最终有可能发展为慢阻肺的人群，如有呼吸道症状、结构异常或功能异常但1秒钟用力呼气容积/用力肺活量（FEV1/FVC）尚正常的人群，即慢阻肺前期人群，将有助于提前开展病因预防即危险因素干预，以及早期治疗干预，以减缓疾病的进展过程。本文针对慢阻肺前期潜在指标的相关研究进行论述，并提出慢阻肺前期未来的研究方向。

英文摘要:

Abstract Chronic obstructive pulmonary disease (COPD) is a disease presenting incompletely reversible and persistent airflow obstruction, which needs a long time to be developed. If individuals who would develop COPD finally could be identified before the disease occurs, such as those with respiratory symptoms, structural or functional abnormalities but normal forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) at present (pre-COPD), interventions regarding risk factors and treatment in early stage could be implemented to slow down the disease progression. In this article we discussed studies relevant to potential indicators for pre-COPD and proposed the research direction of pre-COPD in the future.