向玉.尼达尼布治疗结缔组织相关性间质性肺炎临床疗效研究[J].内科急危重症杂志,2024,30(5):404-406
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| DOI：10.11768/nkjwzzzz.20240505 |
| 中文关键词: 结缔组织相关性间质性肺炎 尼达尼布 细胞因子 |
| 英文关键词: |
| 基金项目:湖北省卫生健康委员会项目（WJ2023F071） |
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| 摘要点击次数: 235 |
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| 中文摘要: |
| 摘要 目的：评估尼达尼布联合常规治疗对结缔组织相关性间质性肺炎(CTD-ILD）的疗效。方法：收集102例CTD-ILD患者作为研究对象,根据临床治疗方案不同将其分为常规治疗组（50例）和尼达尼布联合治疗组（52例），疗程6个月。比较2组患者治疗前、治疗6个月后临床症状、肺功能、肺部高分辨CT评分及血清细胞因子水平的变化。结果：尼达尼布联合治疗组血清细胞因子、肺部高分辨CT评分较治疗前明显降低，肺功能明显改善（P均＜0.05）。结论：尼达尼布联合常规糖皮质激素抗炎治疗可降低CTD-ILD患者血清细胞因子水平，减轻体内炎症反应，改善肺功能，有助于延缓CTD-ILD患者的肺纤维化进展。 |
| 英文摘要: |
| Abstract Objective: To evaluate the efficacy of Nintedanib combined with conventional treatment for connective tissue-associated interstitial pneumonia (CTD-ILD). Methods: A total of 102 patients with CTD-ILD were collected and divided into conventional treatment group (50 cases) and Nintedanib combined treatment group (52 cases) for 6 months according to different clinical treatment plans. The changes of clinical symptoms, lung functions, high resolution CT scores and serum cytokine levels were compared before and 6 months after treatment in 2 groups. Results: The serum cytokines and lung high resolution CT scores in Nintedanib combined treatment group were significantly lower than those before treatment, and the lung function was significantly improved (all P< 0.05). Conclusion: Nintedanib combined with conventional glucocorticoid anti-inflammatory therapy can reduce serum cytokine levels in CTD-ILD patients, reduce inflammation in vivo, improve lung function, and help delay the progression of pulmonary fibrosis in CTD-ILD patients. |
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